Phenotypes associated with this allele

• Allele Symbol: Ltbp3^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3723580
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltbp3^m1Btlr/Ltbp3^m1Btlr	either: C57BL/6J-Ltbp3^m1Btlr or (involves: C3H/HeJ * C57BL/6J)	MGI:3723581

Genotype
MGI:3723581

hm1

• Allelic Composition: Ltbp3^m1Btlr/Ltbp3^m1Btlr
• Genetic Background: either: C57BL/6J-Ltbp3^m1Btlr or (involves: C3H/HeJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:124993 )

• homozygous mutant mice exhibit craniofacial malformation

skeleton

kyphosis ( J:124993 )

• homozygous mutant mice develop progressively severe kyphosis that is prominent by 6 months of age

abnormal synchondrosis ( J:124993 )

• histological analysis of homozygous mutants reveals abnormal formation of synchondroses

behavior/neurological

hindlimb paralysis ( J:124993 )

• by 2 weeks of age, paralysis of the hind legs of homozygous mutant mice is evident

growth/size/body

postnatal growth retardation ( J:124993 )

• growth of homozygous mutants is retarded early in life, but they later grow normally

vision/eye

excessive tearing ( J:124993 )

• by 2 weeks of age, mice homozygous for this mutation exhibit watery eyes