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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-tetX,lacZ)2Gogo
transgene insertion 2, Joseph Gogos
MGI:3723433
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Bdnftm1(BDNF)Gogo/Bdnf+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/? 		involves: 129S/SvEv MGI:3723437
cx2
 		Bdnftm2(BDNF)Gogo/Bdnf+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/? 		involves: 129S/SvEv MGI:3723439
cx3
 		Bdnftm1Jae/Bdnf+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/? 		involves: 129S4/SvJae * C57BL/6 MGI:3723444
cx4
 		Ngfrtm1Jae/Ngfrtm1Jae
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/? 		involves: 129S4/SvJae * C57BL/6 MGI:3723445
cx5
 		Ngfrtm1Jae/Ngfr+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/? 		involves: 129S4/SvJae * C57BL/6 MGI:3723452
cx6
 		Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/? 		Not Specified MGI:3723455


Genotype
MGI:3723437
cx1
Allelic
Composition		 Bdnftm1(BDNF)Gogo/Bdnf+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1(BDNF)Gogo mutation (0 available); any Bdnf mutation (41 available)
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:124050 )
N
• following doxycycline treatment, terminal-arbor complexity and total length of olfactory nerve axons is normal




Genotype
MGI:3723439
cx2
Allelic
Composition		 Bdnftm2(BDNF)Gogo/Bdnf+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm2(BDNF)Gogo mutation (0 available); any Bdnf mutation (41 available)
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory nerve morphology ( J:124050 )
• following doxycycline treatment, terminal-arbor complexity at P6 is reduced similar to in Tg(tetO-tetX,lacZ)2Gogo Omptm1(tTA)Gogo mice




Genotype
MGI:3723444
cx3
Allelic
Composition		 Bdnftm1Jae/Bdnf+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Jae mutation (2 available); any Bdnf mutation (41 available)
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:124050 )
N
• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is normal




Genotype
MGI:3723445
cx4
Allelic
Composition		 Ngfrtm1Jae/Ngfrtm1Jae
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (30 available)
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory nerve morphology ( J:124050 )
• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is rescued with 7 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omptm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice but branching length is not restored




Genotype
MGI:3723452
cx5
Allelic
Composition		 Ngfrtm1Jae/Ngfr+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (30 available)
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory nerve morphology ( J:124050 )
• following doxycycline treatment, terminal-arbor complexity is partially rescued (4 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omptm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice)




Genotype
MGI:3723455
cx6
Allelic
Composition		 Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory nerve morphology ( J:124050 )
• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited
• following doxycycline treatment, P6 mice exhibit a reduction in terminal-arbor complexity (1.96+/-0.17 branches per axon arbor compared to 6.6+/-0.19 in wild-type mice) and total length (153.29+/-13.16 um compared to 231.6+/-0.19 um in wild-type mice)
• following doxycycline treatment, large axonal varicosities are increased as are signs of degeneration
• however, normal branching can be reconstituted with the application of an NMDR inhibitor (MK-801)




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory