Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpsb2tm1(cre)Adch mutation
(0 available);
any
Tpsb2 mutation
(12 available)
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immune system
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• a substantially reduced ability to combat K. pneumoniae infections of their peritoneal cavities
• produced normal-sized litters, showed no obvious developmental abnormality, and had a normal lifespan when maintained in a pathogen-free animal facility
• the peritoneal mast cells showed no substantial alteration in their size or shape or in the numbers, size and density of their secretory granules
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpsab1m1 mutation
(0 available);
any
Tpsab1 mutation
(15 available)
Tpsb2tm1(cre)Adch mutation
(0 available);
any
Tpsb2 mutation
(12 available)
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immune system
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• synovial mast cells do not express the mMcp-6 and -7 proteases
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• there is a signifcant decrease in clinical measurements of joint inflammation induced by Tg(TcraR28,TcrbR28)KRNDim (i.e. K/BxN) mouse serum compared to C57BL/6 controls
• ankle thickness is also less than controls 10 days after arthritis induction
• histological scores of bone and cartilage erosion, as well as inflammation, are also significantly reduced
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skeleton
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• there is a signifcant decrease in clinical measurements of joint inflammation induced by Tg(TcraR28,TcrbR28)KRNDim (i.e. K/BxN) mouse serum compared to C57BL/6 controls
• ankle thickness is also less than controls 10 days after arthritis induction
• histological scores of bone and cartilage erosion, as well as inflammation, are also significantly reduced
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hematopoietic system
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• synovial mast cells do not express the mMcp-6 and -7 proteases
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cellular
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• synovial mast cells do not express the mMcp-6 and -7 proteases
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Analysis Tools