Phenotypes associated with this allele

• Allele Symbol: Trpc2^tm2Mom
• Allele Name: targeted mutation 2, Peter Mombaerts
• Allele ID: MGI:3722352
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gucy1b2^tm2Mom/Gucy1b2^tm2Mom Trpc2^tm2Mom/Trpc2^tm2Mom	B6;129P2-Trpc2^tm2Mom Gucy1b2^tm2Mom/Mom	MGI:5804173
cx2	Cnga2^tm1Mom/Cnga2^tm1Mom Trpc2^tm2Mom/Trpc2^tm2Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:5804192
cx3	Cnga2^tm1Mom/Y Trpc2^tm2Mom/Trpc2^tm2Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:5804197

Genotype
MGI:5804173

cx1

• Allelic Composition: Gucy1b2^tm2Mom/Gucy1b2^tm2Mom; Trpc2^tm2Mom/Trpc2^tm2Mom
• Genetic Background: B6;129P2-Trpc2^tm2Mom Gucy1b2^tm2Mom/Mom

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal olfactory sensory neuron physiology ( J:235858 )

• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl

behavior/neurological

behavior/neurological phenotype ( J:235858 )

N • despite the failures of type B olfactory sensory neurons, homozygotes perform normally in a Morris water maze assay for place learning, spatial memory, and spatial navigation

abnormal sensory capabilities/reflexes/nociception ( J:235858 )

• in a conditioned place aversion test to an area of low oxygen these homozygotes fail to display a preference away from the low oxygen area consistent with the failure of type B olfactory sensory neurons to respond to low oxygen

homeostasis/metabolism

abnormal homeostasis ( J:235858 )

• fail to avoid low oxygen areas due to the failure of type B olfactory sensory neurons to detect decreased oxygen

abnormal physiological response to hypoxia ( J:235858 , J:307157 )

• Type B olfactory sensory neurons have normal calcium flux responses to NaHS, 8-bromo-cGMP and KCl but lack the correct response to reduced oxygen levels (J:307157)

nervous system

abnormal olfactory sensory neuron physiology ( J:235858 )

• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl

respiratory system

abnormal olfactory sensory neuron physiology ( J:235858 )

• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl

Genotype
MGI:5804192

cx2

• Allelic Composition: Cnga2^tm1Mom/Cnga2^tm1Mom; Trpc2^tm2Mom/Trpc2^tm2Mom
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

nervous system

abnormal olfactory sensory neuron physiology ( J:235858 )

• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent

taste/olfaction

abnormal olfactory sensory neuron physiology ( J:235858 )

• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent

respiratory system

abnormal olfactory sensory neuron physiology ( J:235858 )

• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent

Genotype
MGI:5804197

cx3

• Allelic Composition: Cnga2^tm1Mom/Y; Trpc2^tm2Mom/Trpc2^tm2Mom
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

nervous system

abnormal olfactory sensory neuron physiology ( J:235858 )

• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent

taste/olfaction

abnormal olfactory sensory neuron physiology ( J:235858 )

• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent

respiratory system

abnormal olfactory sensory neuron physiology ( J:235858 )

• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent