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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pgk1-FGF2)16Cofn
transgene insertion 16, J Douglas Coffin
MGI:3722245
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Pgk1-FGF2)16Cofn/0 involves: FVB/N MGI:3722248


Genotype
MGI:3722248
tg1
Allelic
Composition		 Tg(Pgk1-FGF2)16Cofn/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal epiphyseal plate morphology ( J:33064 )
• similar to Tg(Pgk1-FGF2)15Cofn mice
abnormal long bone epiphyseal plate proliferative zone ( J:33064 )
• similar to Tg(Pgk1-FGF2)15Cofn mice
chondrodystrophy ( J:33064 )
• not as severe as seen in Tg(Pgk1-FGF2)15Cofn and Tg(Pgk1-FGF2)48Cofn mice

muscle
vascular smooth muscle hypertrophy ( J:33064 )
• smooth muscle cells are hypertrophic compared to control cells, with 66% more protein content than control cells

cardiovascular system
vascular smooth muscle hypertrophy ( J:33064 )
• smooth muscle cells are hypertrophic compared to control cells, with 66% more protein content than control cells

growth/size/body
megacephaly ( J:33064 )
• not as severe as seen in Tg(Pgk1-FGF2)15Cofn and Tg(Pgk1-FGF2)48Cofn mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory