Analysis Tools
mortality/aging
|
• essentially all mice die by 80 days of age, compared to ~50% of Tg(APP)6209Kha single transgenics by 150 days
|
|
Allele Symbol Allele Name Allele ID |
Tg(Pgk1-FGF2)15Cofn transgene insertion 15, J Douglas Coffin MGI:3722189 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• essentially all mice die by 80 days of age, compared to ~50% of Tg(APP)6209Kha single transgenics by 150 days
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die sooner than Tg(APPV717I)1130Kha single transgenics
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• both sexes show displacement of weight gain during growth from weaning to 50 days of age; females remain smaller than nontransgenic littermates, whereas males have similar body weights to controls at 50 days of age
|
|
• severe
|
|
• calvaria are enlarged over occipital bones
|
|
• ulna shows unusual angle of bending
|
|
• calvaria are enlarged over occipital bones
|
|
• ulna shows unusual angle of bending
|
|
• 20-30% shortening of ulna, radius, humerus, femur, and tibia, relative to controls
|
|
• ribs adjacent to thoracic vertebrae are enlarged and flattened at proximal and distal ends
|
|
• appear enlarged and misshapen
|
|
• cervical vertebrae appear compressed, with surface irregularities
|
|
• significant differences are observed between transgenic mice and controls for bone length per gram body weight
|
|
• smooth muscle cells are hypertrophic compared to control cells, with 66% more protein content than control cells
|
|
• smooth muscle cells are hypertrophic compared to control cells, with 66% more protein content than control cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• scar thickness 4 weeks post-infarct induction is greater than in wild-type mice (0.64+/-0.07 mm compared to 0.30+/-0.04 mm in wild-type mice)
• however, infarct size and scar contraction are the same as in wild-type mice
• following infarct induction, mice exhibit increased cardiomyocyte hypertrophy (47% increase in cross-section area compared to 19% increase in cross-section area in wild-type mice)
• fibroblast proliferation at 2 days, 4 days and 1 week post-infarct induction is increased more than twice compared to in wild-type mice while total duration of proliferation is shorter than in wild-type mice
• interstitial fibrosis is exaggerated compared to in wild-type mice following infarct induction (81% compared to 58% in similarly treated wild-type mice)
|
|
• scar thickness 4 weeks post-infarct induction is greater than in wild-type mice (0.64+/-0.07 mm compared to 0.30+/-0.04 mm in wild-type mice)
• however, infarct size and scar contraction are the same as in wild-type mice
• following infarct induction, mice exhibit increased cardiomyocyte hypertrophy (47% increase in cross-section area compared to 19% increase in cross-section area in wild-type mice)
• fibroblast proliferation at 2 days, 4 days and 1 week post-infarct induction is increased more than twice compared to in wild-type mice while total duration of proliferation is shorter than in wild-type mice
• interstitial fibrosis is exaggerated compared to in wild-type mice following infarct induction (81% compared to 58% in similarly treated wild-type mice)
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||