Phenotypes associated with this allele

• Allele Symbol: Txnrd1^tm1.1Ees
• Allele Name: targeted mutation 1.1, Edward E Schmidt
• Allele ID: MGI:3722092
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Txnrd1^tm1.1Ees/Txnrd1^tm1.1Ees	B6.129X1-Txnrd1^tm1.1Ees	MGI:3722804

Genotype
MGI:3722804

hm1

• Allelic Composition: Txnrd1^tm1.1Ees/Txnrd1^tm1.1Ees
• Genetic Background: B6.129X1-Txnrd1^tm1.1Ees

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:124356 )

• no embryos are recovered after E8.5 when mice are present in expected Mendelian ratios

embryo

failure to gastrulate ( J:124356 )

embryonic growth arrest ( J:124356 )

• embryonic development is arrested at the pre-streak stage, mesoderm does not form, embryonic tissues are reduced, and patterning of embryonic tissues is either arrested or incorrect resulting in a failure to gastrulate

abnormal embryonic tissue morphology ( J:124356 )

• at E8.5, embryos are three times the size they were at E7.5 and appear to be undifferentiated ectoderm, expanded into a highly organized structure

absent embryonic epiblast ( J:124356 )

• at E7.5, embryonic ectoderm (epiblast) does not differentiate

failure of primitive streak formation ( J:124356 )

• at E7.5

increased trophoblast giant cell number ( J:124356 )

• at E8.5, trophoblast giant cells are abundant

abnormal visceral endoderm morphology ( J:124356 )

• at E7.5, visceral endoderm morphology resembles that of the extraembryonic region

• at E8.5, visceral endoderm with extraembryonic morphology is expanded, vacuolated and folded upon itself into a thick layer