Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shbtm1.1Miwe mutation
(0 available);
any
Shb mutation
(31 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shbtm1.1Miwe mutation
(0 available);
any
Shb mutation
(31 available)
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mortality/aging
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• fewer than expected embryos are born
• however, mice that are born are viable, fertile and show no obvious defects
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embryo
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• mice produced from null parents exhibit severe malformations including resorptions or loss of embryo structures and mild malformations including tail rotation defects, neural tube closure defects or superficial hemorrhaging
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• some mice have an open neural tube
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cardiovascular system
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• some mice exhibit external hemorrhaging
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limbs/digits/tail
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• some mice have tail defects such as a twisted tail
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nervous system
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• some mice have an open neural tube
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Allelic
Composition |
Shbtm1.1Miwe/Shb+
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Genetic
Background |
involves: 129X1/SvJ * C57BL/6 * FVB/N |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shbtm1.1Miwe mutation
(0 available);
any
Shb mutation
(31 available)
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embryo
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• authors state that the defects similar to those seen in homozygous mice are present in heterozygotes when one parent is homozygous and the other heterozygous for the null allele
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reproductive system
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• maternal inheritance of the null allele is increased
• at E10.5, mice carrying a maternal copy of the null allele were more common than those carrying a maternal wild-type copy
• transmission rations of wild-type to null allele are 31% to 54% at E10.5 and 19% to 81% during ovulation
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Analysis Tools