All Phenotypes Hhex<tm2Cwb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hhex^tm1Cwb/Hhex^tm2Cwb Tg(Alb1-cre)1Khk/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3721920
cn2	Hhex^tm2Cwb/Hhex^tm2Cwb Tg(Alb1-cre)1Khk/?	involves: 129S1/Sv * C57BL/6 * SJL	MGI:3721919
cn3	Hhex^tm1Cwb/Hhex^tm2Cwb Tg(Foxa3-cre)1Khk/?	involves: 129X1/SvJ * C57BL/6 * DBA * SJL	MGI:3721922

Allelic Composition	Hhex^tm1Cwb/Hhex^tm2Cwb Tg(Alb1-cre)1Khk/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhex^tm1Cwb mutation (0 available); any Hhex mutation (16 available)
Hhex^tm2Cwb mutation (1 available); any Hhex mutation (16 available)
Tg(Alb1-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal bile duct development ( J:124126 )

• intrahepatic bile duct morphogenesis is abnormal and results in hepatic cysts

abnormal liver morphology ( J:124126 )

• at E18.5, the portal tracts are often surrounded by many irregular biliary duct-like structures/cysts

• mice exhibit a ductal plate malformation

• in the liver, the portal vein is surrounded by multiple cysts (likely of biliary cell origin) and irregular duct-like structures

liver cyst ( J:124126 )

• at E18.5, the portal tracts are often surrounded by many irregular biliary duct-like structures/cysts

• cysts present in the parenchymal tissue appear to form in the absence of a branch of the portal vein

• at 8 weeks, 24 of 26 mice have cysts and four of these mice have more than 50 visible cysts

• cysts are seen in all lobes of the liver, multioculated, almost all filled with a clear fluid, range in size from 0.5mm to 8mm, and worsen with age

• hepatic cysts are a result of abnormal morphogenesis of the intrahepatic bile duct

endocrine/exocrine glands

abnormal bile duct development ( J:124126 )

• intrahepatic bile duct morphogenesis is abnormal and results in hepatic cysts

growth/size/body

liver cyst ( J:124126 )

• at E18.5, the portal tracts are often surrounded by many irregular biliary duct-like structures/cysts

• cysts present in the parenchymal tissue appear to form in the absence of a branch of the portal vein

• at 8 weeks, 24 of 26 mice have cysts and four of these mice have more than 50 visible cysts

• cysts are seen in all lobes of the liver, multioculated, almost all filled with a clear fluid, range in size from 0.5mm to 8mm, and worsen with age

• hepatic cysts are a result of abnormal morphogenesis of the intrahepatic bile duct

Allelic Composition	Hhex^tm2Cwb/Hhex^tm2Cwb Tg(Alb1-cre)1Khk/?
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhex^tm2Cwb mutation (1 available); any Hhex mutation (16 available)
Tg(Alb1-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver cyst ( J:124126 )

• by 43 weeks, mice have developed severe cystic disease

growth/size/body

liver cyst ( J:124126 )

• by 43 weeks, mice have developed severe cystic disease

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:124126 )

liver/biliary system

abnormal extrahepatic bile duct morphology ( J:124126 )

• at E13.5, the extrahepatic bile duct (EHBD) is absent and normal EHBD epithelium is replaced by pseudostratified epithelium resembling the duodenum

• at E16.5, the duodenal-like mucosa extends from the duodenum to the liver hilum

abnormal hepatic duct morphology ( J:124126 )

• at E16.5, dilated hepatic ducts and biliary cysts lined by cuboidal epithelium are present at the liver hilum

biliary cyst ( J:124126 )

• at E16.5, biliary cysts are present at the liver hilum

absent gallbladder ( J:124126 )

• at E10.5, gall bladder primordium could not be detected by Onecut1 staining

abnormal liver morphology ( J:124126 )

• at E16.5, the ventral liver periphery has lost its cohesive structure and bloods cells are trapped or pool in this region

• at E18.5, normal hepatic architecture is disrupted

abnormal intrahepatic bile duct morphology ( J:124126 )

• at E18.5, livers exhibit large dilated duct-like structures

liver cyst ( J:124126 )

• at E18.5, livers are extremely cystic with large dilated duct-like structures and many smaller cysts

liver hypoplasia ( J:124126 )

• at E13.5, the liver is hypoplastic

endocrine/exocrine glands

abnormal extrahepatic bile duct morphology ( J:124126 )

• at E13.5, the extrahepatic bile duct (EHBD) is absent and normal EHBD epithelium is replaced by pseudostratified epithelium resembling the duodenum

• at E16.5, the duodenal-like mucosa extends from the duodenum to the liver hilum

abnormal hepatic duct morphology ( J:124126 )

• at E16.5, dilated hepatic ducts and biliary cysts lined by cuboidal epithelium are present at the liver hilum

abnormal intrahepatic bile duct morphology ( J:124126 )

• at E18.5, livers exhibit large dilated duct-like structures

biliary cyst ( J:124126 )

• at E16.5, biliary cysts are present at the liver hilum

absent gallbladder ( J:124126 )

• at E10.5, gall bladder primordium could not be detected by Onecut1 staining

growth/size/body

biliary cyst ( J:124126 )

• at E16.5, biliary cysts are present at the liver hilum

liver cyst ( J:124126 )

• at E18.5, livers are extremely cystic with large dilated duct-like structures and many smaller cysts

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