Phenotypes associated with this allele

• Allele Symbol: Egfl7^tm1Wye
• Allele Name: targeted mutation 1, Weilan Ye
• Allele ID: MGI:3721404
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Egfl7^tm1Wye/Egfl7^tm1Wye	B6.129-Egfl7^tm1Wye	MGI:3723052

Genotype
MGI:3723052

hm1

• Allelic Composition: Egfl7^tm1Wye/Egfl7^tm1Wye
• Genetic Background: B6.129-Egfl7^tm1Wye

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:124110 )

• many mice die between E14.5 and E15.5: about 50% lethality occurs in utero

cardiovascular system

abnormal blood vessel morphology ( J:124110 )

• vasculature in adult mice is tortuous

• authors state that the phenotypes observed are consistent with the phenotypes observed in Egfl7^{Gt(OST80956)Lex} homozygotes

abnormal retina vasculature morphology ( J:124110 )

• at P5, retinal vascular coverage is reduced

• defect in adult retina vasculature include tortuous arteries, aberrant association between vessels of similar diameter, irregular vessel diameter along its length, vessels that form loops and knots, and some primary vessels that penetrate the outer plexiform layer

abnormal vascular development ( J:124110 )

• at E12.5 and E14.5, mice exhibit decreased coronary vascular coverage and reduced cranial vasculature complexity

vision/eye

abnormal retina vasculature morphology ( J:124110 )

• at P5, retinal vascular coverage is reduced

• defect in adult retina vasculature include tortuous arteries, aberrant association between vessels of similar diameter, irregular vessel diameter along its length, vessels that form loops and knots, and some primary vessels that penetrate the outer plexiform layer