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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3tm1Tsc
targeted mutation 1, Jurg Tschopp
MGI:3721141
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp3tm1Tsc/Nlrp3tm1Tsc C57BL/6-Nlrp3tm1Tsc MGI:3721964
hm2
 		Nlrp3tm1Tsc/Nlrp3tm1Tsc involves: C57BL/6 MGI:5007934
cx3
 		Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Nlrp3tm1Tsc/Nlrp3tm1Tsc 		involves: 129S6/SvEvTac * C57BL/6 MGI:5007933


Genotype
MGI:3721964
hm1
Allelic
Composition		 Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic
Background		 C57BL/6-Nlrp3tm1Tsc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Tsc mutation (0 available); any Nlrp3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:124226 )
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), IL-1-beta release from peritoneal macrophages is impaired




Genotype
MGI:5007934
hm2
Allelic
Composition		 Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Tsc mutation (0 available); any Nlrp3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:172117 )
• bone marrow CD11b+ cells stimulated with LPS and ATP fail to secrete IL1beta unlike wild-type cells




Genotype
MGI:5007933
cx3
Allelic
Composition		 Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mefvtm5.1(MEFV)Chae mutation (0 available); any Mefv mutation (44 available)
Nlrp3tm1Tsc mutation (0 available); any Nlrp3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased interleukin-1 beta secretion ( J:172117 )
• bone marrow CD11b+ cells and bone marrow-derived dendritic cells secrete IL1beta when stimulated with LPS alone, unlike wild-type cells
increased inflammatory response ( J:172117 )
• mice exhibit inflammatory phenotypes observed in Mefvtm5.1(MEFV)Chae homozygotes

growth/size/body
decreased body weight ( J:172117 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory