Phenotypes associated with this allele

• Allele Symbol: Nlrp3^tm1Tsc
• Allele Name: targeted mutation 1, Jurg Tschopp
• Allele ID: MGI:3721141
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrp3^tm1Tsc/Nlrp3^tm1Tsc	C57BL/6-Nlrp3^tm1Tsc	MGI:3721964
hm2	Nlrp3^tm1Tsc/Nlrp3^tm1Tsc	involves: C57BL/6	MGI:5007934
cx3	Mefv^tm5.1(MEFV)Chae/Mefv^tm5.1(MEFV)Chae Nlrp3^tm1Tsc/Nlrp3^tm1Tsc	involves: 129S6/SvEvTac * C57BL/6	MGI:5007933

Genotype
MGI:3721964

hm1

• Allelic Composition: Nlrp3^tm1Tsc/Nlrp3^tm1Tsc
• Genetic Background: C57BL/6-Nlrp3^tm1Tsc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), IL-1-beta release from peritoneal macrophages is impaired

Genotype
MGI:5007934

hm2

• Allelic Composition: Nlrp3^tm1Tsc/Nlrp3^tm1Tsc
• Genetic Background: involves: C57BL/6

immune system

decreased interleukin-1 beta secretion ( J:172117 )

• bone marrow CD11b+ cells stimulated with LPS and ATP fail to secrete IL1beta unlike wild-type cells

Genotype
MGI:5007933

cx3

• Allelic Composition: Mefv^{tm5.1(MEFV)Chae}/Mefv^{tm5.1(MEFV)Chae}; Nlrp3^tm1Tsc/Nlrp3^tm1Tsc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

immune system

increased interleukin-1 beta secretion ( J:172117 )

• bone marrow CD11b+ cells and bone marrow-derived dendritic cells secrete IL1beta when stimulated with LPS alone, unlike wild-type cells

increased inflammatory response ( J:172117 )

• mice exhibit inflammatory phenotypes observed in Mefv^{tm5.1(MEFV)Chae} homozygotes

growth/size/body

decreased body weight ( J:172117 )