All Phenotypes Atf2<tm1Nicj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atf2^tm1Nicj
targeted mutation 1, Nic Jones
MGI:3720850

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atf2^tm1Nicj/Atf2^tm1Nicj	B6.129P2-Atf2^tm1Nicj	MGI:3721129
cx2	Atf2^tm1Nicj/Atf2^tm1Nicj Atf7^tm1Nicj/Atf7^tm1Nicj	involves: 129P2/OlaHsd * C57BL/6	MGI:3721133

Allelic Composition	Atf2^tm1Nicj/Atf2^tm1Nicj
Genetic Background	B6.129P2-Atf2^tm1Nicj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2^tm1Nicj mutation (0 available); any Atf2 mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:123909 )

• authors state that mice have a similar phenotype to that observed in Atf2^tm2Nicj homozygotes

homeostasis/metabolism

cyanosis ( J:123909 )

• authors state that mice have a similar phenotype to that observed in Atf2^tm2Nicj homozygotes

Allelic Composition	Atf2^tm1Nicj/Atf2^tm1Nicj Atf7^tm1Nicj/Atf7^tm1Nicj
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2^tm1Nicj mutation (0 available); any Atf2 mutation (89 available)
Atf7^tm1Nicj mutation (0 available); any Atf7 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:123909 )

• pups die between E11.5 and E12.5

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:123909 )

• E12.5 myeloid and erythroid precursors from the liver form fewer hematopoeitic colonies compared to wild-type cells

anemia ( J:123909 )

• some pups recovered between E11.5 and E12.5 are anemic

embryo

embryonic growth arrest ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit developmental arrest and death

embryonic growth retardation ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

growth/size/body

embryonic growth retardation ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

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