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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nsun7Ste5Jcs1
sterile 5 John C Schimenti 1
MGI:3720682
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nsun7Ste5Jcs1/Nsun7Ste5Jcs1 involves: C3HeB/FeJ * C57BL/6 MGI:3721386
hm2
 		Nsun7Ste5Jcs1/Nsun7Ste5Jcs1 involves: C57BL/6 MGI:3721387


Genotype
MGI:3721386
hm1
Allelic
Composition		 Nsun7Ste5Jcs1/Nsun7Ste5Jcs1
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nsun7Ste5Jcs1 mutation (0 available); any Nsun7 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
asthenozoospermia ( J:100332 )
• sperm motility is impaired

reproductive system
asthenozoospermia ( J:100332 )
• sperm motility is impaired




Genotype
MGI:3721387
hm2
Allelic
Composition		 Nsun7Ste5Jcs1/Nsun7Ste5Jcs1
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nsun7Ste5Jcs1 mutation (0 available); any Nsun7 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm midpiece morphology ( J:124143 )
• the midpiece section of the flagellum is abnormally rigid and fails to contribute to flagellar bending
abnormal sperm mitochondrial sheath morphology ( J:124143 )
• sperm mitochondrial sheath exhibits abnormal electron density
abnormal sperm motility ( J:124143 )
• mice have a lower percentage of motile sperm than in wild-type mice
• sperm swim in slow circles, exhibit slow swimming velocities and fail to make forward progress
decreased litter size ( J:124143 )
• some males produce small litters
reduced male fertility ( J:124143 )
• over a long period of time 53% of males can sire litters

cellular
abnormal sperm midpiece morphology ( J:124143 )
• the midpiece section of the flagellum is abnormally rigid and fails to contribute to flagellar bending
abnormal sperm mitochondrial sheath morphology ( J:124143 )
• sperm mitochondrial sheath exhibits abnormal electron density
abnormal sperm motility ( J:124143 )
• mice have a lower percentage of motile sperm than in wild-type mice
• sperm swim in slow circles, exhibit slow swimming velocities and fail to make forward progress




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory