Phenotypes associated with this allele

• Allele Symbol: Pdcd1lg2^tm2Shr
• Allele Name: targeted mutation 2, Arlene H Sharpe
• Allele ID: MGI:3720327
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdcd1lg2^tm2Shr/Pdcd1lg2^tm2Shr	C.B6-Pdcd1lg2^tm2Shr	MGI:3721512

Genotype
MGI:3721512

hm1

• Allelic Composition: Pdcd1lg2^tm2Shr/Pdcd1lg2^tm2Shr
• Genetic Background: C.B6-Pdcd1lg2^tm2Shr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal dendritic cell physiology ( J:123785 )

• bone marrow dendritic cells increases the production of IL-2 and interferon-gamma from transgenic DO11 T cells in vitro by 20% to 50% when compared to wild-type cells

increased interferon-gamma secretion ( J:123785 )

• in an in vitro assay with dendritic cell or an adoptive transfer experiment into mice, DO11 transgenic T cells are modestly stimulated to over-produce interferon-gamma

increased interleukin-2 secretion ( J:123785 )

• in an in vitro assay with dendritic cell or an adoptive transfer experiment into mice, DO11 transgenic T cells are modestly stimulated to over-produce IL-2

• in an adoptive transfer experiment into mice, IL-4+ DO11 transgenic cells are reduced by 60%