Analysis Tools
mortality/aging
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• when treated with the a 0.1 mg/kg dose of echothiophate (the LD50 dose for wild-type mice), no F5 generation transgenic mice die compared to 3/8 wild-type animals, indicating that transgene expression confers protection from organophosphate toxicity
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behavior/neurological
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• F5 generation mice show only slight tremors, compared to wild-type mice that show severe signs of toxicity like whole body tremor when treated with 0.1 mg/kg echothiophate
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homeostasis/metabolism
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• transgenic mice show similar murine Bche activity to wild-type, indicating that expression of the human enzyme does not affect endogenous enzyme production or activity
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• echothiophate-treated transgenic mice show slight salivation in contrast to wild-type mice which show profuse salivation
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• no significant decrease in body temperature is exhibited by transgenics treated with echothiophate, whereas wild-type mice show a dramatic drop in body temperature
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• when treated with the a 0.1 mg/kg dose of echothiophate (the LD50 dose for wild-type mice), no F5 generation transgenic mice die compared to 3/8 wild-type animals, indicating that transgene expression confers protection from organophosphate toxicity
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endocrine/exocrine glands
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• echothiophate-treated transgenic mice show slight salivation in contrast to wild-type mice which show profuse salivation
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digestive/alimentary system
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• echothiophate-treated transgenic mice show slight salivation in contrast to wild-type mice which show profuse salivation
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