Phenotypes associated with this allele

• Allele Symbol: Glis2^tm1Tre
• Allele Name: targeted mutation 1, Mathias Treier
• Allele ID: MGI:3719836
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glis2^tm1Tre/Glis2^tm1Tre	B6.129P2-Glis2^tm1Tre	MGI:3720098

Genotype
MGI:3720098

hm1

• Allelic Composition: Glis2^tm1Tre/Glis2^tm1Tre
• Genetic Background: B6.129P2-Glis2^tm1Tre

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased renal tubule apoptosis ( J:123510 )

• at week 4

abnormal kidney morphology ( J:123510 )

• corticomedullary differentiation is lost

kidney cortex cyst ( J:123510 )

• tubular and glomerular cysts develop

kidney cortex atrophy ( J:123510 )

• the cortex becomes atrophic at 4 weeks; more pronounced at 8 weeks

renal interstitial fibrosis ( J:123510 )

• mice develop fibrosis and deposition of collagen

kidney medulla atrophy ( J:123510 )

• the inner medulla and outer medulla become atrophic at 4 weeks; more pronounced at 8 weeks

decreased kidney weight ( J:123510 )

• at 4 weeks to 6 months, kidney weight and size is decreased to 0.14 g and 120 ul from wild-type mice with a weight of 0.22 g and volume of 180 ul

renal tubule atrophy ( J:123510 )

• mice exhibit tubular atrophy

cellular

increased renal tubule apoptosis ( J:123510 )

• at week 4

growth/size/body

kidney cortex cyst ( J:123510 )

• tubular and glomerular cysts develop

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nephronophthisis 7		DOID:0111116	OMIM:611498	J:123510