Phenotypes associated with this allele

• Allele Symbol: H2-T23^tm2Cant
• Allele Name: targeted mutation 2, Harvey Cantor
• Allele ID: MGI:3719723
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-T23^tm2Cant/H2-T23^tm2Cant	B6.129S6-H2-T23^tm2Cant	MGI:3822039
hm2	H2-T23^tm2Cant/H2-T23^tm2Cant	involves: 129S6/SvEvTac	MGI:3813813
cx3	H2-T23^tm2Cant/H2-T23^tm2Cant Tg(Tcra2D2,Tcrb2D2)1Kuch/?	involves: 129S6/SvEvTac	MGI:3822040

Genotype
MGI:3822039

hm1

• Allelic Composition: H2-T23^tm2Cant/H2-T23^tm2Cant
• Genetic Background: B6.129S6-H2-T23^tm2Cant

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )

• four-fold more activated CD4 T cells are susceptible to natural killer cell lysis in vitro

• CD4 T cells fail to proliferate when transferred into an immunodeficient host

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:142087 )

• mice respond strongly to the protective effects of pre-treatment with an encephalomyelitic peptide before EAE induction, with no disease developing compared to controls that develop a mild disease

• CD4 T cells isolated from mice in this disease model produce fail to produce inflammatory cytokines when activated

• transfer of EAE by transplant of CD4 T cells into an immunodeficent host can be completely blocked compared to controls by co-transfer of CD8 T regulatory cells

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )

• four-fold more activated CD4 T cells are susceptible to natural killer cell lysis in vitro

• CD4 T cells fail to proliferate when transferred into an immunodeficient host

Genotype
MGI:3813813

hm2

• Allelic Composition: H2-T23^tm2Cant/H2-T23^tm2Cant
• Genetic Background: involves: 129S6/SvEvTac

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:123555 )

• CD4+ cells are not protected from natural killer cells

• survival of CD4+ lymphocytes is substantially reduced

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:123555 )

• CD4+ cells are not protected from natural killer cells

• survival of CD4+ lymphocytes is substantially reduced

Genotype
MGI:3822040

cx3

• Allelic Composition: H2-T23^tm2Cant/H2-T23^tm2Cant; Tg(Tcra2D2,Tcrb2D2)1Kuch/?
• Genetic Background: involves: 129S6/SvEvTac

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )

• CD4 T cells are highly susceptible to dose-dependent suppression by CD8 T regulatory cells in vitro

• this suppression is dependent on Fas ligand being expressed by the CD8 T regulatory cell

increased susceptibility to experimental autoimmune encephalomyelitis ( J:142087 )

• transfer of CD4 T cells into Rag2^-/^- Prf1^-/^- hosts initiates a progressive and lethal form of EAE that results in death from fulminant disease within 14?16 days after transfer

• co-transfer of CD8 T regulatory cells with mutant CD4 T cells prevents disease where as co-transfer of CD8 T regulatory cells with transgenic CD4 T cells not carrying the H2-T23 mutation fails to prevent disease

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )

• CD4 T cells are highly susceptible to dose-dependent suppression by CD8 T regulatory cells in vitro

• this suppression is dependent on Fas ligand being expressed by the CD8 T regulatory cell