Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
Foxp3tm4(YFP/icre)Ayr mutation
(2 available);
any
Foxp3 mutation
(55 available)
Tgfb1tm2Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
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growth/size/body
 N |
• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi mice
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hematopoietic system
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• in the peripheral and mesenteric lymph nodes, but not the spleen
• 2-fold increase in mesenteric regulatory T cell
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immune system
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N |
• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi mice
• mice exhibit normal susceptibility to experimental autoimmune encephalomyelitis and Th17 cell differentiation
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• in the peripheral and mesenteric lymph nodes, but not the spleen
• 2-fold increase in mesenteric regulatory T cell
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
Tgfb1tm2Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
Tnfrsf4tm2(cre)Nik mutation
(1 available);
any
Tnfrsf4 mutation
(33 available)
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immune system
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• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa
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• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
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• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
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• in an experimental autoimmune encephalomyelitis model
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• almost complete resistance
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• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice
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• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice
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growth/size/body
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• mild beginning at 5 months
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digestive/alimentary system
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• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa
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liver/biliary system
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• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice
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respiratory system
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• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice
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hematopoietic system
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• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
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• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
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• in an experimental autoimmune encephalomyelitis model
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cellular
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
Foxp3tm1Flv mutation
(3 available);
any
Foxp3 mutation
(55 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
Tgfb1tm2Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
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immune system
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• Foxp3+ regulatory T cells are increased 2-fold relative to wild-type mice
• the numbers of regulatory T cells is increased in the peripheral and mesenteric lymph nodes, spleens and among the lamina propria mononuclear cell infiltrate of the colon
• proliferation of Foxp3+ cells and CD4+CD8+Foxp3- cells is increased in association with the development of colitis
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hematopoietic system
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• Foxp3+ regulatory T cells are increased 2-fold relative to wild-type mice
• the numbers of regulatory T cells is increased in the peripheral and mesenteric lymph nodes, spleens and among the lamina propria mononuclear cell infiltrate of the colon
• proliferation of Foxp3+ cells and CD4+CD8+Foxp3- cells is increased in association with the development of colitis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
Tgfb1tm2Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
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mortality/aging
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• mice begin to die at 6 months of age due to wasting and diarrhea
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immune system
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• T cells Th1, Th2 and CTL (cytotoxic T lymphocyte) differentiation is enhanced while Th17-cell differentiation is inhibited
• in the experimental autoimmune encephalomyelitis model, the number of IL-17 producing T cells is reduced in animals that do and those that do not develop encephalomyelitis
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• as determined by transplantation experiments, defects in Th17 cell differentiation occur in an autocrine manner
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• T cell activation is enhanced
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• following activation, interferon-gamma levels are increased relative to in control cells
• in the experimental autoimmune encephalomyelitis model, only mice that develop encephalomyelitis produce great amounts of interferon-gamma
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• following activation, IL-4 levels are increased whereas IL-17 levels are decreased relative to in control cells
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• 6 of 8 mice did not develop encephalomyelitis and only 2 showed mild disease compared to controls which all develop severe disease
• the number of IL-17 producing T cells is reduced in animals that do and those that do not develop encephalomyelitis
• only mice that develop encephalomyelitis produce great amounts of interferon-gamma
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• mice present with mononuclear infiltrate in the lungs, parenchyma of the liver, and colon
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• severe colitis is associated with disruption of the crypt architecture, crypt abscess formation and epithelium hyperplasia
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digestive/alimentary system
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• epithelium hyperplasia is associated with colitis
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• disruption of crypt architecture is associated with colitis
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• associated with colitis
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• at 4 to 12 months of age, heavy mononuclear cell infiltrate of the lamina propria and subglandular areas of the colon is detected
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• severe colitis is associated with disruption of the crypt architecture, crypt abscess formation and epithelium hyperplasia
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growth/size/body
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• at 4 months of age mice display signs of wasting
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liver/biliary system
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• mononuclear cell clusters are detected in the parenchyma of mice with colitis
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renal/urinary system
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• IgG deposits accumulate in the glomeruli
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respiratory system
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• mononuclear cell infiltrate is present in the lungs of mice with colitis
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endocrine/exocrine glands
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• disruption of crypt architecture is associated with colitis
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• associated with colitis
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hematopoietic system
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• T cells Th1, Th2 and CTL (cytotoxic T lymphocyte) differentiation is enhanced while Th17-cell differentiation is inhibited
• in the experimental autoimmune encephalomyelitis model, the number of IL-17 producing T cells is reduced in animals that do and those that do not develop encephalomyelitis
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• as determined by transplantation experiments, defects in Th17 cell differentiation occur in an autocrine manner
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• T cell activation is enhanced
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homeostasis/metabolism
cellular
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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hematopoietic system
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• regulatory T cells fail to drive Th17 differentiation
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immune system
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• regulatory T cells fail to drive Th17 differentiation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
Tg(CD207-cre)1Dhka mutation
(1 available)
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immune system
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• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters
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hematopoietic system
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• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
Tg(CD207-cre)1Dhka mutation
(1 available)
Tgfb1tm2Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
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immune system
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• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1tm1Flv mice
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hematopoietic system
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• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1tm1Flv mice
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Analysis Tools