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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab8atm1Aha
targeted mutation 1, Akihiro Harada
MGI:3719350
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rab8atm1Aha/Rab8atm1Aha Not Specified MGI:3720324


Genotype
MGI:3720324
hm1
Allelic
Composition		 Rab8atm1Aha/Rab8atm1Aha
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab8atm1Aha mutation (0 available); any Rab8a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123415 )
• mice die 3 to 4 weeks after birth

digestive/alimentary system
diarrhea ( J:123415 )
• at 2.5 to 3 weeks
abnormal small intestine morphology ( J:123415 )
• small intestines are swollen and contain undigested milk
decreased small intestinal microvillus size ( J:123415 )
• microvilli are shortened and contain inclusion bodies
abnormal intestinal absorption ( J:123415 )
• nutrient uptake is abolished in the small intestine

cellular
accumulation of giant lysosomes in kidney/renal tubule cells ( J:123415 )
• 2 to 2.5 weeks, lysosomes accumulate beneath the apical plasma membrane of the tubules

growth/size/body
cachexia ( J:123415 )
• at 2.5 to 3 weeks

renal/urinary system
accumulation of giant lysosomes in kidney/renal tubule cells ( J:123415 )
• 2 to 2.5 weeks, lysosomes accumulate beneath the apical plasma membrane of the tubules




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory