Phenotypes associated with this allele

• Allele Symbol: Ubr3^tm1Ytkw
• Allele Name: targeted mutation 1, Yong Tae Kwon
• Allele ID: MGI:3718505
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ubr3^tm1Ytkw/Ubr3^tm1Ytkw	129S1/SvImJ-Ubr3^tm1Ytkw	MGI:3718792
hm2	Ubr3^tm1Ytkw/Ubr3^tm1Ytkw	B6.129S1-Ubr3^tm1Ytkw	MGI:3718793
hm3	Ubr3^tm1Ytkw/Ubr3^tm1Ytkw	involves: 129S1/Sv * C57BL/6	MGI:3718791

Genotype
MGI:3718792

hm1

• Allelic Composition: Ubr3^tm1Ytkw/Ubr3^tm1Ytkw
• Genetic Background: 129S1/SvImJ-Ubr3^tm1Ytkw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:123383 )

• Background Sensitivity: in coisogenic 129S1 background, no homozygous mutant mice were retrieved from E3.5 to E16.5 embryos from heterozygous intercrosses, suggesting early embryonic lethality unlike in mixed B6/129S1 or congenic B6 background

Genotype
MGI:3718793

hm2

• Allelic Composition: Ubr3^tm1Ytkw/Ubr3^tm1Ytkw
• Genetic Background: B6.129S1-Ubr3^tm1Ytkw

mortality/aging

postnatal lethality, incomplete penetrance ( J:123383 )

• Background Sensitivity: in congenic B6 background, homozygous mutant embryos were apparently normal in growth and other developmental features, but about 60% of mutant neonates died within 2 days after birth due to inability to suckle milk unlike in mixed B6/129S1 or coisogenic 129S1 background

• the surviving mice grew to adulthood without significant growth retardation and were fertile, with normal mating behavior

behavior/neurological

abnormal suckling behavior ( J:123383 )

• about 60% of homozygous mutant pups exhibited impaired mild suckling

• body color, breathing behavior, touch response, righting, and vocalization are all normal at birth

• affected homogeneous mice after death did not exhibit significant anatomical abnormalities in the palate, mouth, and esophagus

growth/size/body

decreased body weight ( J:123383 )

• about 10% lower body weight compared to wild-type siblings at birth

homeostasis/metabolism

abnormal noradrenaline level ( J:123383 )

• significantly reduced level of noradrenaline in the olfactory bulb

taste/olfaction

anosmia ( J:123383 )

• exhibit the behavioral anosmia in female

Genotype
MGI:3718791

hm3

• Allelic Composition: Ubr3^tm1Ytkw/Ubr3^tm1Ytkw
• Genetic Background: involves: 129S1/Sv * C57BL/6

mortality/aging

mortality/aging ( J:123383 )

N • Background Sensitivity: mutant mice in mixed B6/129S1 background were born at a frequency slightly lower than the expected Mendelian frequency unlike mutant mice in congenic B6 or coisogenic 129S1 background