All Phenotypes Tg(Wnt1-En1)1Amc MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Wnt1-En1)1Amc
transgene insertion 1, Andrew P McMahon
MGI:3718490

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	En1^tm1Alj/En1^tm1Alj Tg(Wnt1-En1)1Amc/0	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:3718801
cx2	En1^tm1Alj/En1^tm1Alj Wnt7a^tm1Amc/Wnt7a^tm1Amc Tg(Wnt1-En1)1Amc/0	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:3718802
cx3	En1^tm1Gld/En1^tm1Gld Tg(Wnt1-En1)1Amc/0	involves: 129S/SvEv	MGI:3839920

Allelic Composition	En1^tm1Alj/En1^tm1Alj Tg(Wnt1-En1)1Amc/0
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
Tg(Wnt1-En1)1Amc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:45301 )

• perinatal brain lethality is rescued

nervous system

abnormal brain morphology ( J:45301 )

• brain abnormalities rescued

limbs/digits/tail

abnormal digit morphology ( J:45301 )

• ectopic hair growth on the ventral surface of the anterior digits

• related to ectopic ventral expression of Lmx-1B

abnormal foot pad morphology ( J:45301 )

• dorsal foot pads at the distal tips of digits 2 and 3 in 3 of 7 mice

Allelic Composition	En1^tm1Alj/En1^tm1Alj Wnt7a^tm1Amc/Wnt7a^tm1Amc Tg(Wnt1-En1)1Amc/0
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
Tg(Wnt1-En1)1Amc mutation (0 available)
Wnt7a^tm1Amc mutation (1 available); any Wnt7a mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:45301 )

• viability ranged from 3 weeks to beyond 4 months

perinatal lethality, incomplete penetrance ( J:45301 )

• born in lower numbers than expected

limbs/digits/tail

abnormal autopod morphology ( J:45301 )

• ventral surface of autopods is pigmented

abnormal digit morphology ( J:45301 )

• dorsal sesamoid processes in the 3rd digit

• no polydactyly

oligodactyly ( J:45301 )

• some mice lack digit 5

abnormal foot pad morphology ( J:45301 )

• ectopic foot pads on digits 2, 3, and 4

• striations on the tips of digits 2, 3, and 5

• hardened foot pads

abnormal forelimb morphology ( J:45301 )

• dorsal surface of forelimbs with ventral surface characteristics

Allelic Composition	En1^tm1Gld/En1^tm1Gld Tg(Wnt1-En1)1Amc/0
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Gld mutation (0 available); any En1 mutation (32 available)
Tg(Wnt1-En1)1Amc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:106437 )

• impaired ability to walk and maintain balance at higher rotarod speeds

• while performance improves with practice mice never match the performance of wild-type controls

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