Phenotypes associated with this allele

• Allele Symbol: Tg(SOD1)51Yg
• Allele Name: transgene insertion 51, Yoram Groner
• Allele ID: MGI:3718455
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(APP)8.9Btla/Tg(APP)8.9Btla Tg(SOD1)51Yg/Tg(SOD1)51Yg	involves: 129S2/SvPas * BALB/c * C57BL/6J * DBA/2	MGI:3718511
tg2	Tg(SOD1)51Yg/Tg(SOD1)51Yg	involves: BALB/c * C57BL/6J * DBA/2	MGI:3718509

Genotype
MGI:3718511

cx1

• Allelic Composition: Tg(APP)8.9Btla/Tg(APP)8.9Btla; Tg(SOD1)51Yg/Tg(SOD1)51Yg
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:96742 )

• 9-month old mice show impaired memory retention in Morris water maze, exhibiting delayed escape latency compared to controls in all 6 trials

impaired short-term object recognition memory ( J:96742 )

• impairment observed at 10 months of age; mice show greater impairment than Tg(APP)8.9Btla mice

increased exploration in new environment ( J:96742 )

• exploratory behavior is increased for both familiar and novel objects

abnormal spatial learning ( J:96742 )

• at 9 months, a delay of learning process in Morris water maze is observed compared to controls; double mutants are significantly impaired relative to controls

• at 4.5 months of age, rate of learning platform position during first day of Morris water maze testing is impaired compared to controls or Tg(APP)8.9Btla/Tg(SOD1)69Yg double mutants

increased anxiety-related response ( J:96742 )

• mice spend greater amounts of time in the closed arms of an elevated plus maze than Tg(SOD1)51Yg or Tg(APP)8.9Btla mice; time per entry into dark arms is increased relative to Tg(APP)8.9Btla mice and total entries into dark arms is greater than controls

• mice spend much more time in dark side of dark-light box than either single transgenic line or controls

abnormal locomotor activation ( J:96742 )

• transgenic mice display more spontaneous locomotor activity than controls

nervous system

abnormal brain morphology ( J:96742 )

• mic show a 2-fold increase of cortical APP proteins and a 2.5-2.8-fold increase in hippocampal APP levels compared to Tg(APP)8.9Btla mice

• no Abeta peptides are detected in 5 month old mice

reduced long-term potentiation ( J:96742 )

• LTP is impaired

Genotype
MGI:3718509

tg2

• Allelic Composition: Tg(SOD1)51Yg/Tg(SOD1)51Yg
• Genetic Background: involves: BALB/c * C57BL/6J * DBA/2

growth/size/body

decreased body size ( J:96742 )

• mice are smaller than Tg(SOD1)69Yg mice

decreased body weight ( J:96742 )

• weight is lower than controls or Tg(SOD1)69Yg mice

behavior/neurological

decreased anxiety-related response ( J:96742 )

• mice spend less time in the closed arms than controls; time/entry is lower than in controls as well

• mice exit dark side of dark-light box more often than controls

abnormal physical strength ( J:96742 )

• exhibit lower muscular strength than non-transgenic control mice

abnormal locomotor activation ( J:96742 )

• transgenic mice display more spontaneous locomotor activity than controls

abnormal pain threshold ( J:96742 )

• lower pain thresholds than non-transgenic controls

nervous system

reduced long-term potentiation ( J:96742 )

• LTP is impaired