Analysis Tools
vision/eye
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• at 6 months, more apoptotic cells are present in the retina than in wild-type mice
• at 17 months, a burst of cell apoptosis occurs and continued through 20 months then decreases to almost none by 26 months
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• mottling of the retinal pigment epithelium is first visible at 5 months of age and area of mottling increased with age
• blood vessels are thinned
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• the outer nuclear layer (ONL) is thinned as early as 6 months, is slow in the first 13 months and accelerates at 17 months
• ONL is thinned down to almost nothing by 26 months
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• at 7, 12 and 18 months mice exhibit photoreceptor and synapse degeneration
• at 20 months, severe retinal degeneration is present and reached end-stage by 26 months
• synapse degeneration is only present when photoreceptor degeneration occurs
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• at 20 months, mice have significantly thinned retinas compared to wild-type mice
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• beginning after 12 months mice have a reduction in a- and b-waves
• mice with severe degeneration have little to no electroretinogram reading
• at 15 months, residual b-waves are detected
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pigmentation
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• mottling of the retinal pigment epithelium is first visible at 5 months of age and area of mottling increased with age
• blood vessels are thinned
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