Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-KLF4)1Rup
• Allele Name: transgene insertion 1, J Michael Ruppert
• Allele ID: MGI:3717765
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(MMTV-KLF4)1Rup/0 Trp53^tm1Brd/Trp53^+	involves: 129S7/SvEvBrd * C57BL/6NTac * FVB/NJ * SJL	MGI:3717873
tg2	Tg(MMTV-KLF4)1Rup/0	involves: 129S7/SvEvBrd * C57BL/6NTac * FVB/NJ * SJL	MGI:3717874

Genotype
MGI:3717873

cx1

• Allelic Composition: Tg(MMTV-KLF4)1Rup/0; Trp53^tm1Brd/Trp53⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6NTac * FVB/NJ * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:96886 )

• lifespan is ~8 months due to sarcomas

neoplasm

increased sarcoma incidence ( J:96886 )

• all mice develop sarcoma outgrowth within the fibrovascular response

• tumors 1-1.5 cm in diameter and are composed of spindled, anaplastic cells and scattered giant cells

integument

abnormal skin morphology ( J:96886 )

• vascular, fibrotic dermis

abnormal dermal layer morphology ( J:96886 )

skin lesions ( J:96886 )

• between 6 and 8 months of age, dorsal skin lesions similar to those in the inducible models develop in all animals

Genotype
MGI:3717874

tg2

• Allelic Composition: Tg(MMTV-KLF4)1Rup/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6NTac * FVB/NJ * SJL

integument

abnormal skin morphology ( J:96886 )

• animals >18 months of age develop severe dysplasia of the dorsal skin or ears

abnormal dermal layer morphology ( J:96886 )

• mice do not develop sarcoma but display a fibrovascular response that includes blood vessels intercalated between basal and parabasal epithelial cells