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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mfge8tm1Mcu
targeted mutation 1, Mark C Udey
MGI:3717588
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mfge8tm1Mcu/Mfge8tm1Mcu involves: 129X1/SvJ * C57BL/6NCr MGI:3718020
cx2
 		Mfge8tm1Mcu/Mfge8tm1Mcu
Tg(RIP1-Tag)2Dh/? 		involves: 129X1/SvJ * C57BL/6J * C57BL/6NCr * DBA/2J MGI:3718021


Genotype
MGI:3718020
hm1
Allelic
Composition		 Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic
Background		 involves: 129X1/SvJ * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8tm1Mcu mutation (0 available); any Mfge8 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:123138 )
• in older mice

hematopoietic system
enlarged spleen ( J:123138 )
• in older mice

growth/size/body
enlarged spleen ( J:123138 )
• in older mice




Genotype
MGI:3718021
cx2
Allelic
Composition		 Mfge8tm1Mcu/Mfge8tm1Mcu
Tg(RIP1-Tag)2Dh/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * C57BL/6NCr * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8tm1Mcu mutation (0 available); any Mfge8 mutation (23 available)
Tg(RIP1-Tag)2Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:123138 )
• there is a decrease in invasive type 2 tumors compared to in Tg(RIP1-Tag)2Dh transgenic mice
abnormal tumor morphology ( J:123138 )
• mice have a 20% reduction in tumor vessel permeability compared to in Tg(RIP1-Tag)2Dh transgenic mice
decreased tumor growth/size ( J:123138 )
• at 12 and 13.5 weeks of age, tumor burden is decreased 2-fold tumor size and incidence is decreased compared to Tg(RIP1-Tag)2Dh transgenic mice
• tumor size and incidence is decreased compared to Tg(RIP1-Tag)2Dh transgenic mice
increased adenoma incidence ( J:123138 )
• adenoma incidence are increased compared to in Tg(RIP1-Tag)2Dh transgenic mice
• apoptotic cells are less frequent in adenomas compared to in hyperblastic and angiogenic islet cells in the same animals and in Tg(RIP1-Tag)2Dh transgenic mice
increased carcinoma incidence ( J:123138 )
• there is a two-fold increase in apoptosis in microinvasive carcinomas

hematopoietic system
decreased Langerhans cell number ( J:123138 )
• the number of angiogenic islets is decreased by 35% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• proliferation of angiogenic islets is decreased by 25% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• hyperplastic and angiogenic islet apoptosis is increased compared to in Tg(RIP1-Tag)2Dh transgenic mice

immune system
decreased Langerhans cell number ( J:123138 )
• the number of angiogenic islets is decreased by 35% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• proliferation of angiogenic islets is decreased by 25% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• hyperplastic and angiogenic islet apoptosis is increased compared to in Tg(RIP1-Tag)2Dh transgenic mice




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory