About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mfge8tm1Mcu
targeted mutation 1, Mark C Udey
MGI:3717588
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mfge8tm1Mcu/Mfge8tm1Mcu involves: 129X1/SvJ * C57BL/6NCr MGI:3718020
cx2
 		Mfge8tm1Mcu/Mfge8tm1Mcu
Tg(RIP1-Tag)2Dh/? 		involves: 129X1/SvJ * C57BL/6J * C57BL/6NCr * DBA/2J MGI:3718021


Genotype
MGI:3718020
hm1
Allelic
Composition		 Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic
Background		 involves: 129X1/SvJ * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8tm1Mcu mutation (0 available); any Mfge8 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:123138 )
• in older mice

hematopoietic system
enlarged spleen ( J:123138 )
• in older mice

growth/size/body
enlarged spleen ( J:123138 )
• in older mice




Genotype
MGI:3718021
cx2
Allelic
Composition		 Mfge8tm1Mcu/Mfge8tm1Mcu
Tg(RIP1-Tag)2Dh/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * C57BL/6NCr * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8tm1Mcu mutation (0 available); any Mfge8 mutation (22 available)
Tg(RIP1-Tag)2Dh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:123138 )
• there is a decrease in invasive type 2 tumors compared to in Tg(RIP1-Tag)2Dh transgenic mice
abnormal tumor morphology ( J:123138 )
• mice have a 20% reduction in tumor vessel permeability compared to in Tg(RIP1-Tag)2Dh transgenic mice
decreased tumor growth/size ( J:123138 )
• at 12 and 13.5 weeks of age, tumor burden is decreased 2-fold tumor size and incidence is decreased compared to Tg(RIP1-Tag)2Dh transgenic mice
• tumor size and incidence is decreased compared to Tg(RIP1-Tag)2Dh transgenic mice
increased adenoma incidence ( J:123138 )
• adenoma incidence are increased compared to in Tg(RIP1-Tag)2Dh transgenic mice
• apoptotic cells are less frequent in adenomas compared to in hyperblastic and angiogenic islet cells in the same animals and in Tg(RIP1-Tag)2Dh transgenic mice
increased carcinoma incidence ( J:123138 )
• there is a two-fold increase in apoptosis in microinvasive carcinomas

hematopoietic system
decreased Langerhans cell number ( J:123138 )
• the number of angiogenic islets is decreased by 35% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• proliferation of angiogenic islets is decreased by 25% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• hyperplastic and angiogenic islet apoptosis is increased compared to in Tg(RIP1-Tag)2Dh transgenic mice

immune system
decreased Langerhans cell number ( J:123138 )
• the number of angiogenic islets is decreased by 35% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• proliferation of angiogenic islets is decreased by 25% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• hyperplastic and angiogenic islet apoptosis is increased compared to in Tg(RIP1-Tag)2Dh transgenic mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory