Analysis Tools
behavior/neurological
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• no alterations in passive avoidance learning are observed
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• 6-month old female mice show significant impairment in learning in the Morris water maze paradigm; mice display no improvement over four consecutive trials
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• mice perform better than other genotypes and controls in the rotorod test, displaying a significantly increased latency to fall from the rod
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nervous system
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• age-related neuronal pathologies observed in Apoe-deficient mice are prevented by transgene expression
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• after injection of 18 mg/kg kainic acid, mice show no disruption of hippocampal axons, whereas wild-type show significant loss of synaptophysin-positive neocortical presynaptic terminals
• mice do not show the same age dependent loss of neocortical and hippocampal presynaptic terminals and neuronal dendrites as Apoe-null and Apoe-null, Apoe3-trangenic mice
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