All Phenotypes Shc1<tm3Paw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shc1^tm3Paw
targeted mutation 3, Tony Pawson
MGI:3716777

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shc1^tm3Paw/Shc1^tm3Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717090
ht2	Shc1^tm3Paw/Shc1^tm7Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717108
ht3	Shc1^tm3Paw/Shc1^tm4Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717109
cn4	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm3Paw/Shc1^tm9Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717104

Allelic Composition	Shc1^tm3Paw/Shc1^tm3Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm3Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:122927 )

• number of viable progeny is reduced to 12.2% compared to 25% expected

Allelic Composition	Shc1^tm3Paw/Shc1^tm7Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm7Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• mice display motor defects more severe than than transheterozygous Shc1^{tm3Paw/tm4Paw} mice

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls

• intrafusal fiber numbers are 35.9% of control numbers

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls

• intrafusal fiber numbers are 35.9% of control numbers

Allelic Composition	Shc1^tm3Paw/Shc1^tm4Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm4Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• mice display more severe motor defects than transheterozygous Shc1^{tm4Paw/tm7Paw} mice

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 83.3% of controls

• intrafusal fiber numbers are 66.6% of control numbers

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 83.3% of controls

• intrafusal fiber numbers are 66.6% of control numbers

Allelic Composition	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm3Paw/Shc1^tm9Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1^tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1^tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• motor abnormalities are similar to those observed in Shc1^tm7Paw homozygotes

impaired limb coordination ( J:122927 )

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

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