Phenotypes associated with this allele

• Allele Symbol: Arc^tm1.1Kuhl
• Allele Name: targeted mutation 1.1, Dietmar Kuhl
• Allele ID: MGI:3716713
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arc^tm1.1Kuhl/Arc^tm1.1Kuhl	involves: 129S1/Sv * 129X1/SvJ	MGI:3717262
hm2	Arc^tm1.1Kuhl/Arc^tm1.1Kuhl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3717260

Genotype
MGI:3717262

hm1

• Allelic Composition: Arc^tm1.1Kuhl/Arc^tm1.1Kuhl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal AMPA-mediated synaptic currents ( J:122964 )

• AMPA receptor function is increased

• AMPA receptor scaling is absent following TTX and bicuculine treatments

abnormal miniature excitatory postsynaptic currents ( J:122964 )

• following TTX treament, mice fail to produce an enhanced miniature excitatory postsynaptic current as wild-type mice do

Genotype
MGI:3717260

hm2

• Allelic Composition: Arc^tm1.1Kuhl/Arc^tm1.1Kuhl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

behavior/neurological

abnormal conditioned taste aversion behavior ( J:122980 )

• mice fail to develop a conditioned taste aversion behavior when saccharin followed by a LiCl injection was used

• however, mice avoid quinine to a similar extent as wild-type mice do

abnormal contextual conditioning behavior ( J:122980 )

• fear-related memory either through cued or contextual conditioning is disrupted

abnormal cued conditioning behavior ( J:122980 )

• fear-related memory either through cued or contextual conditioning is disrupted

impaired long-term object recognition memory ( J:122980 )

• mice fail to develop long-term recognition memory

abnormal spatial learning ( J:122980 )

• mice fail to demonstrate improved performance during the late acquisition stage as wild-type mice do in a Morris water maze

• mice are less precise in processing spatial information and less flexible in relearning

• spatial memory formation is impaired

decreased fear-related response ( J:122980 )

• mice freeze less in response to a cued or contextual conditioned fear stimuli

nervous system

nervous system phenotype ( J:122980 )

N • brain morphology is normal

enhanced long-term potentiation ( J:122980 )

• early long term potential is enhanced

reduced long-term potentiation ( J:122980 )

• late phase long term potential is impaired