Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rint1tm1Whl mutation
(0 available);
any
Rint1 mutation
(37 available)
|
|
|
mortality/aging
|
• embryos die at E5.5
• only empty deciduas and remains of resorbed embryos are found from E6 to E12.5
|
embryo
|
• pups are poorly developed at E5.5
• mouse embryonic fibroblasts collected from E3.5 embryos fail to expand after 4 days in culture and die later
|
reproductive system
|
• only empty deciduas and remains of resorbed embryos are found from E6 to E12.5
|
Allelic Composition |
Rint1tm1Whl/Rint1+
|
|
Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rint1tm1Whl mutation
(0 available);
any
Rint1 mutation
(37 available)
|
|
|
mortality/aging
|
• average lifespan is 24 months
|
neoplasm
|
• 81% of mice develop multiple tumors
|
|
• mammary gland malignant phyllodes tumors develop in 3% of mice
|
|
• mammary gland adenocarcinomas develop in 3% of mice
|
|
• ovarian dysgerminomas develop in 3% of mice
|
|
• neck keratoacanthoma in 3% of mice
|
|
• skin squamous carcinomas develop in 3% of mice
|
|
• hepatocellular carcinomas develop in 7% of mice
|
|
• uterus leiomyoma (in 3% of mice)
|
|
• cystoadenoma in 3% of mice
|
|
• hemangioendotheliomas develop in 3% of mice
|
|
• peritoneum malignant mesothelioma (in 6% of mice)
|
|
• anus squamous cell papillomas develop in 3% of mice
|
integument
|
• mammary gland malignant phyllodes tumors develop in 3% of mice
|
|
• mammary gland adenocarcinomas develop in 3% of mice
|
|
• neck keratoacanthoma in 3% of mice
|
|
• skin squamous carcinomas develop in 3% of mice
|
respiratory system
endocrine/exocrine glands
|
• mammary gland malignant phyllodes tumors develop in 3% of mice
|
|
• mammary gland adenocarcinomas develop in 3% of mice
|
|
• ovarian dysgerminomas develop in 3% of mice
|
liver/biliary system
|
• hepatocellular carcinomas develop in 7% of mice
|
muscle
|
• uterus leiomyoma (in 3% of mice)
|
nervous system
reproductive system
|
• ovarian dysgerminomas develop in 3% of mice
|
|
• uterus leiomyoma (in 3% of mice)
|