Phenotypes associated with this allele

• Allele Symbol: Rint1^tm1Whl
• Allele Name: targeted mutation 1, Wen-Hwa Lee
• Allele ID: MGI:3716054
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rint1^tm1Whl/Rint1^tm1Whl	Not Specified	MGI:3716703
ht2	Rint1^tm1Whl/Rint1^+	Not Specified	MGI:3716704

Genotype
MGI:3716703

hm1

• Allelic Composition: Rint1^tm1Whl/Rint1^tm1Whl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:122805 )

• embryos die at E5.5

• only empty deciduas and remains of resorbed embryos are found from E6 to E12.5

embryo

abnormal embryo development ( J:122805 )

• pups are poorly developed at E5.5

• mouse embryonic fibroblasts collected from E3.5 embryos fail to expand after 4 days in culture and die later

reproductive system

empty decidua capsularis ( J:122805 )

• only empty deciduas and remains of resorbed embryos are found from E6 to E12.5

Genotype
MGI:3716704

ht2

• Allelic Composition: Rint1^tm1Whl/Rint1⁺
• Genetic Background: Not Specified

mortality/aging

premature death ( J:122805 )

• average lifespan is 24 months

neoplasm

increased tumor incidence ( J:122805 )

• 81% of mice develop multiple tumors

increased pituitary adenoma incidence ( J:122805 )

• in 6% of mice

increased mammary gland tumor incidence ( J:122805 )

• mammary gland malignant phyllodes tumors develop in 3% of mice

increased mammary adenocarcinoma incidence ( J:122805 )

• mammary gland adenocarcinomas develop in 3% of mice

increased ovary tumor incidence ( J:122805 )

♀ • ovarian dysgerminomas develop in 3% of mice

increased keratoacanthoma incidence ( J:122805 )

• neck keratoacanthoma in 3% of mice

increased skin squamous cell carcinoma incidence ( J:122805 )

• skin squamous carcinomas develop in 3% of mice

increased hepatocellular carcinoma incidence ( J:122805 )

• hepatocellular carcinomas develop in 7% of mice

increased uterus leiomyoma incidence ( J:122805 )

♀ • uterus leiomyoma (in 3% of mice)

increased cystadenoma incidence ( J:122805 )

• cystoadenoma in 3% of mice

increased hemangioma incidence ( J:122805 )

• hemangioendotheliomas develop in 3% of mice

increased lymphoma incidence ( J:122805 )

• in 29% of mice

increased lung adenocarcinoma incidence ( J:122805 )

• in 13% of mice

increased mesothelioma incidence ( J:122805 )

• peritoneum malignant mesothelioma (in 6% of mice)

increased papilloma incidence ( J:122805 )

• anus squamous cell papillomas develop in 3% of mice

integument

increased mammary gland tumor incidence ( J:122805 )

• mammary gland malignant phyllodes tumors develop in 3% of mice

increased mammary adenocarcinoma incidence ( J:122805 )

• mammary gland adenocarcinomas develop in 3% of mice

increased keratoacanthoma incidence ( J:122805 )

• neck keratoacanthoma in 3% of mice

increased skin squamous cell carcinoma incidence ( J:122805 )

• skin squamous carcinomas develop in 3% of mice

respiratory system

increased lung adenocarcinoma incidence ( J:122805 )

• in 13% of mice

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:122805 )

• in 6% of mice

increased mammary gland tumor incidence ( J:122805 )

• mammary gland malignant phyllodes tumors develop in 3% of mice

increased mammary adenocarcinoma incidence ( J:122805 )

• mammary gland adenocarcinomas develop in 3% of mice

increased ovary tumor incidence ( J:122805 )

♀ • ovarian dysgerminomas develop in 3% of mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:122805 )

• hepatocellular carcinomas develop in 7% of mice

muscle

increased uterus leiomyoma incidence ( J:122805 )

♀ • uterus leiomyoma (in 3% of mice)

nervous system

increased pituitary adenoma incidence ( J:122805 )

• in 6% of mice

reproductive system

increased ovary tumor incidence ( J:122805 )

♀ • ovarian dysgerminomas develop in 3% of mice

increased uterus leiomyoma incidence ( J:122805 )

♀ • uterus leiomyoma (in 3% of mice)