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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Klf6tm1Fdmn
targeted mutation 1, Scott L Friedman
MGI:3715995
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Klf6tm1Fdmn/Klf6tm1Fdmn involves: C57BL/6 MGI:3716722
ht2
 		Klf6tm1Fdmn/Klf6+ involves: C57BL/6 MGI:3716721
ht3
 		Klf6tm1Fdmn/Klf6+ Not Specified MGI:3717435


Genotype
MGI:3716722
hm1
Allelic
Composition		 Klf6tm1Fdmn/Klf6tm1Fdmn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf6tm1Fdmn mutation (0 available); any Klf6 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal vitelline vasculature morphology ( J:122926 )
• vasculature is poorly defined
abnormal visceral yolk sac morphology ( J:122926 )
• yolk sacs are much thinner and disorganized with few blood cells

cellular
decreased cell proliferation ( J:122926 )
• on feeder cells, mouse embryonic fibroblast cells have a 20% greater doubling time than wild-type cells
• on gelatinized dishes, mouse embryonic fibroblast cells have a 50% greater doubling time than wild-type cells
• after 6 days in culture, embryoid bodies are reduced in number by 80%

growth/size/body
decreased body size ( J:122926 )
• at E10.5, pups are small and pale in appearance

liver/biliary system
abnormal liver development ( J:122926 )
• at E10.5, mice have no liver

cardiovascular system
abnormal vitelline vasculature morphology ( J:122926 )
• vasculature is poorly defined

integument
pallor ( J:122926 )
• at E10.5




Genotype
MGI:3716721
ht2
Allelic
Composition		 Klf6tm1Fdmn/Klf6+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf6tm1Fdmn mutation (0 available); any Klf6 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal embryonic hematopoiesis ( J:122926 )
• embryoid bodies have reduced or delayed hematopoeitic development

embryo
abnormal embryonic hematopoiesis ( J:122926 )
• embryoid bodies have reduced or delayed hematopoeitic development




Genotype
MGI:3717435
ht3
Allelic
Composition		 Klf6tm1Fdmn/Klf6+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf6tm1Fdmn mutation (0 available); any Klf6 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system

growth/size/body
increased body weight ( J:122903 )
increased liver weight ( J:122903 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory