Phenotypes associated with this allele

• Allele Symbol: Klf6^tm1Fdmn
• Allele Name: targeted mutation 1, Scott L Friedman
• Allele ID: MGI:3715995
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf6^tm1Fdmn/Klf6^tm1Fdmn	involves: C57BL/6	MGI:3716722
ht2	Klf6^tm1Fdmn/Klf6^+	involves: C57BL/6	MGI:3716721
ht3	Klf6^tm1Fdmn/Klf6^+	Not Specified	MGI:3717435

Genotype
MGI:3716722

hm1

• Allelic Composition: Klf6^tm1Fdmn/Klf6^tm1Fdmn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:122926 )

• lethality is apparent by E12.5

embryo

abnormal vitelline vasculature morphology ( J:122926 )

• vasculature is poorly defined

abnormal visceral yolk sac morphology ( J:122926 )

• yolk sacs are much thinner and disorganized with few blood cells

cellular

decreased cell proliferation ( J:122926 )

• on feeder cells, mouse embryonic fibroblast cells have a 20% greater doubling time than wild-type cells

• on gelatinized dishes, mouse embryonic fibroblast cells have a 50% greater doubling time than wild-type cells

• after 6 days in culture, embryoid bodies are reduced in number by 80%

growth/size/body

decreased body size ( J:122926 )

• at E10.5, pups are small and pale in appearance

liver/biliary system

abnormal liver development ( J:122926 )

• at E10.5, mice have no liver

cardiovascular system

abnormal vitelline vasculature morphology ( J:122926 )

• vasculature is poorly defined

integument

pallor ( J:122926 )

• at E10.5

Genotype
MGI:3716721

ht2

• Allelic Composition: Klf6^tm1Fdmn/Klf6⁺
• Genetic Background: involves: C57BL/6

hematopoietic system

abnormal embryonic hematopoiesis ( J:122926 )

• embryoid bodies have reduced or delayed hematopoeitic development

embryo

abnormal embryonic hematopoiesis ( J:122926 )

• embryoid bodies have reduced or delayed hematopoeitic development

Genotype
MGI:3717435

ht3

• Allelic Composition: Klf6^tm1Fdmn/Klf6⁺
• Genetic Background: Not Specified

liver/biliary system

increased liver weight ( J:122903 )

growth/size/body

increased body weight ( J:122903 )

increased liver weight ( J:122903 )