All Phenotypes Shisa2<tm1Sia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shisa2^tm1Sia
targeted mutation 1, Shinichi Aizawa
MGI:3715222

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shisa2^tm1Sia/Shisa2^tm1Sia	involves: C57BL/6 * CBA	MGI:3715231
cx2	Lefty1^tm1Hmd/Lefty1^tm1Hmd Shisa2^tm1Sia/Shisa2^tm1Sia	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3718480
cx3	Lefty2^tm1Hmd/Lefty2^tm1Hmd Shisa2^tm1Sia/Shisa2^tm1Sia	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3718481
cx4	Cer1^tm1Belo/Cer1^tm1Belo Shisa2^tm1Sia/Shisa2^tm1Sia	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3718479

Allelic Composition	Shisa2^tm1Sia/Shisa2^tm1Sia
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shisa2^tm1Sia mutation (0 available); any Shisa2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:122557 )

• half of mice die within the first month

growth/size/body

proportional dwarf ( J:122557 )

• two thirds of mice

postnatal growth retardation ( J:122557 )

nervous system

abnormal hypothalamus morphology ( J:122557 )

• dying dwarf mice exhibit abnormal thalamus with an expansion of the space between the cerebrum and thalamus

Allelic Composition	Lefty1^tm1Hmd/Lefty1^tm1Hmd Shisa2^tm1Sia/Shisa2^tm1Sia
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lefty1^tm1Hmd mutation (1 available); any Lefty1 mutation (41 available)
Shisa2^tm1Sia mutation (0 available); any Shisa2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:122557 )

N	• no defects in anterior neuroectoderm development are detected

Allelic Composition	Lefty2^tm1Hmd/Lefty2^tm1Hmd Shisa2^tm1Sia/Shisa2^tm1Sia
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lefty2^tm1Hmd mutation (1 available); any Lefty2 mutation (14 available)
Shisa2^tm1Sia mutation (0 available); any Shisa2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:122557 )

N	• no defects in anterior neuroectoderm development are detected

Allelic Composition	Cer1^tm1Belo/Cer1^tm1Belo Shisa2^tm1Sia/Shisa2^tm1Sia
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cer1^tm1Belo mutation (0 available); any Cer1 mutation (11 available)
Shisa2^tm1Sia mutation (0 available); any Shisa2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:122557 )

N	• no defects in anterior neuroectoderm development are detected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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