About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shisa2tm1Sia
targeted mutation 1, Shinichi Aizawa
MGI:3715222
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Shisa2tm1Sia/Shisa2tm1Sia involves: C57BL/6 * CBA MGI:3715231
cx2
 		Lefty1tm1Hmd/Lefty1tm1Hmd
Shisa2tm1Sia/Shisa2tm1Sia 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3718480
cx3
 		Lefty2tm1Hmd/Lefty2tm1Hmd
Shisa2tm1Sia/Shisa2tm1Sia 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3718481
cx4
 		Cer1tm1Belo/Cer1tm1Belo
Shisa2tm1Sia/Shisa2tm1Sia 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:3718479


Genotype
MGI:3715231
hm1
Allelic
Composition		 Shisa2tm1Sia/Shisa2tm1Sia
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shisa2tm1Sia mutation (0 available); any Shisa2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:122557 )
• half of mice die within the first month

growth/size/body
proportional dwarf ( J:122557 )
• two thirds of mice
postnatal growth retardation ( J:122557 )

nervous system
abnormal hypothalamus morphology ( J:122557 )
• dying dwarf mice exhibit abnormal thalamus with an expansion of the space between the cerebrum and thalamus




Genotype
MGI:3718480
cx2
Allelic
Composition		 Lefty1tm1Hmd/Lefty1tm1Hmd
Shisa2tm1Sia/Shisa2tm1Sia
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lefty1tm1Hmd mutation (1 available); any Lefty1 mutation (41 available)
Shisa2tm1Sia mutation (0 available); any Shisa2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:122557 )
N
• no defects in anterior neuroectoderm development are detected




Genotype
MGI:3718481
cx3
Allelic
Composition		 Lefty2tm1Hmd/Lefty2tm1Hmd
Shisa2tm1Sia/Shisa2tm1Sia
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lefty2tm1Hmd mutation (1 available); any Lefty2 mutation (14 available)
Shisa2tm1Sia mutation (0 available); any Shisa2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:122557 )
N
• no defects in anterior neuroectoderm development are detected




Genotype
MGI:3718479
cx4
Allelic
Composition		 Cer1tm1Belo/Cer1tm1Belo
Shisa2tm1Sia/Shisa2tm1Sia
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cer1tm1Belo mutation (0 available); any Cer1 mutation (12 available)
Shisa2tm1Sia mutation (0 available); any Shisa2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:122557 )
N
• no defects in anterior neuroectoderm development are detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory