Phenotypes associated with this allele

• Allele Symbol: Npnt^tm1.1Lfr
• Allele Name: targeted mutation 1.1, Louis F Reichardt
• Allele ID: MGI:3715213
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npnt^tm1.1Lfr/Npnt^tm1.1Lfr	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3715475
ht2	Npnt^tm1.1Lfr/Npnt^+	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3715476

Genotype
MGI:3715475

hm1

• Allelic Composition: Npnt^tm1.1Lfr/Npnt^tm1.1Lfr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:122519 )

N • basement membrane is intact during kidney development

abnormal kidney morphology ( J:122519 )

• some kidneys show cystic or dysplastic elements

abnormal kidney development ( J:122519 )

• in 2/4 mutants examined at E13.5, no kidney development was seen and metanephric mesenchyme was atrophying; in 1 of 4 embryos, a kidney was developing on one side while in 1 of 4, kidney development on both sides occurred

small kidney ( J:122519 )

• kidneys are smaller than those of wild-type littermates

absent kidney ( J:122519 )

• some animals lack one (23%) or both (46%) kidneys; remainder (31%) have two kidneys

impaired branching involved in ureteric bud morphogenesis ( J:122519 )

• at E11.5, embryos show no evidence of ureteric bud branching or invasion of the metanephric mesenchyme

• by E12.5, extent of branching is variable with either one or two rounds of branching, compared to three rounds in wild-type

• ureteric bud formation is normal, but there is failure to invade metanephric mesenchyme

Genotype
MGI:3715476

ht2

• Allelic Composition: Npnt^tm1.1Lfr/Npnt⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

renal/urinary system

single kidney ( J:122519 )

• 2/109 mice exhibit unilateral kidney agenesis