Phenotypes associated with this allele
Allelic Composition |
Pcsk1tm1Mbi/Pcsk1tm1Mbi
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcsk1tm1Mbi mutation
(0 available);
any
Pcsk1 mutation
(50 available)
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mortality/aging
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• homozygous embryos are observed in significant numbers at the 1-cell (31%) and 2-cell (19%) stages, but is below 5% at 4- and 8-cell stages, and is 0% at later stages
• when fertilized eggs from heterozygous crosses are cultured, by day 5, 94% of homozygous embryos reach the blastocyst stage compared to 86% for wild-type embryos. Homozygous embryos show a delay in reaching morula stage by day 3, but catch up on day 4 and start growing slightly faster than wild-type on days 5 and 6
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Allelic Composition |
Pcsk1tm1Mbi/Pcsk1+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcsk1tm1Mbi mutation
(0 available);
any
Pcsk1 mutation
(50 available)
|
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growth/size/body
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• after 13 weeks on a low fat diet, females show less weight gain (9%) than wild-type females (26%); male heterozygotes gain a comparable amount of weight as wild-type mice
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• on a high fat diet, female heterozygotes gain 43% more weight on a high fat diet compared to a 9% weight gain on a low fat diet; both heterozygous and wild-type males show more weight gain (40%) than shown when on low fat diet (~23%)
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homeostasis/metabolism
reproductive system
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• frequency of mutant allele among surviving embryos (after implantation to weaning age) is consistently >80%, instead of the expected 66.7%
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