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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nkd2tm1Kwha
targeted mutation 1, Keith Wharton
MGI:3714464
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nkd2tm1Kwha/Nkd2tm1Kwha involves: 129S/SvEv MGI:3714506
hm2
 		Nkd2tm1Kwha/Nkd2tm1Kwha involves: 129S/SvEv * C57BL/6 MGI:3714503
ht3
 		Nkd2tm1Kwha/Nkd2+ involves: 129S/SvEv MGI:3714505
ht4
 		Nkd2tm1Kwha/Nkd2+ involves: 129S/SvEv * C57BL/6 MGI:3714504
cx5
 		Nkd1tm1Kwha/Nkd1+
Nkd2tm1Kwha/Nkd2+ 		involves: 129S/SvEv * C57BL/6 MGI:3714515
cx6
 		Nkd1tm1Kwha/Nkd1tm1Kwha
Nkd2tm1Kwha/Nkd2tm1Kwha 		involves: 129S/SvEv * C57BL/6 MGI:3714516


Genotype
MGI:3714506
hm1
Allelic
Composition		 Nkd2tm1Kwha/Nkd2tm1Kwha
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd2tm1Kwha mutation (1 available); any Nkd2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased litter size ( J:122353 )
• Background Sensitivity: mean litter size of homozygous intercrosses is reduced (4.5 pups) compared to litters observed on mixed background (6.4 pups)

skeleton
skeleton phenotype ( J:122353 )
N
• skeletons show no consistent differences relative to wild-type in terms of bone mass or morphology




Genotype
MGI:3714503
hm2
Allelic
Composition		 Nkd2tm1Kwha/Nkd2tm1Kwha
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd2tm1Kwha mutation (1 available); any Nkd2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:122353 )
N
• size and growth rate is normal relative to wild-type

reproductive system
reproductive system phenotype ( J:122353 )
N
• 3-month old males had similar testis-to-body weight as controls and normal spermatogenesis
• Background Sensitivity: average litter size from homozygous intercrosses is 6.4 pups compared to 4.5 pups on the 129 background

skeleton
skeleton phenotype ( J:122353 )
N
• skeletons show no consistent differences relative to wild-type in terms of bone mass and morphology




Genotype
MGI:3714505
ht3
Allelic
Composition		 Nkd2tm1Kwha/Nkd2+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd2tm1Kwha mutation (1 available); any Nkd2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:122353 )
N
• mice are viable and fertile




Genotype
MGI:3714504
ht4
Allelic
Composition		 Nkd2tm1Kwha/Nkd2+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd2tm1Kwha mutation (1 available); any Nkd2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:122353 )
N
• mice are fertile




Genotype
MGI:3714515
cx5
Allelic
Composition		 Nkd1tm1Kwha/Nkd1+
Nkd2tm1Kwha/Nkd2+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd1tm1Kwha mutation (1 available); any Nkd1 mutation (17 available)
Nkd2tm1Kwha mutation (1 available); any Nkd2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
pup cannibalization ( J:122353 )
• significantly higher rate of cannabilization of offspring prior to weaning is observed in females having no or one wild-type copy of Nkd1 or Nkd2 (35% of 46 litters of females with one or no wild-type copies of either allele compared to only 14% of 51 litters of Nkd1-null or Nkd2-null homozygous females)




Genotype
MGI:3714516
cx6
Allelic
Composition		 Nkd1tm1Kwha/Nkd1tm1Kwha
Nkd2tm1Kwha/Nkd2tm1Kwha
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd1tm1Kwha mutation (1 available); any Nkd1 mutation (17 available)
Nkd2tm1Kwha mutation (1 available); any Nkd2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:122353 )
N
• mice are viable and fertile

behavior/neurological
pup cannibalization ( J:122353 )
• significantly higher rate of cannabilization of offspring prior to weaning is observed in females having no or one wild-type copy of Nkd1 or Nkd2 (35% of 46 litters of females with one or no wild-type copies of either allele compared to only 14% of 51 litters of Nkd1-null or Nkd2-null homozygous females)

craniofacial
decreased cranium height ( J:122353 )
• at 2 months, skulls of mice are slightly shortened
short nasal bone ( J:122353 )
• at 2 months, nasal bones are slightly shortened relative to controls

skeleton
decreased cranium height ( J:122353 )
• at 2 months, skulls of mice are slightly shortened
short nasal bone ( J:122353 )
• at 2 months, nasal bones are slightly shortened relative to controls

growth/size/body
short nasal bone ( J:122353 )
• at 2 months, nasal bones are slightly shortened relative to controls

respiratory system
short nasal bone ( J:122353 )
• at 2 months, nasal bones are slightly shortened relative to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory