Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd1tm1Kwha mutation
(1 available);
any
Nkd1 mutation
(17 available)
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reproductive system
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• Background Sensitivity: homozygous matings produce fewer litters (6 mating pairs - 1 litter) on 129/SvEv background compared to those of homozygotes on mixed background (6 mating pairs - 19 litters)
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• Background Sensitivity: mean litter size of homozygous intercrosses is reduced (1 pup) compared to litters observed on mixed background (5.3 pups) or litters of heterozygous intercrosses regardless of genetic background (4.9-7.3 pups)
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skeleton
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N |
• Background Sensitivity: skeletons show no consistent differences relative to wild-type in terms of bone mass or morphology
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd1tm1Kwha mutation
(1 available);
any
Nkd1 mutation
(17 available)
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growth/size/body
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• Background Sensitivity: nasal bones are slightly shortened relative to controls or homozygotes on the mixed background
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• Background Sensitivity: 4- to 12-week old pups fed ad libitum show a slight but significant growth retardation (15% in males at 12 weeks, 4.6% in females at 12 weeks) compared to wild-type mice
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reproductive system
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N |
• Background Sensitivity: mice are viable and fertile; average litter size is 7.3
• 3-month old males had similar testis-to-body weight as controls and normal spermatogenesis
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craniofacial
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• Background Sensitivity: nasal bones are slightly shortened relative to controls or homozygotes on the mixed background
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skeleton
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• Background Sensitivity: nasal bones are slightly shortened relative to controls or homozygotes on the mixed background
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respiratory system
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• Background Sensitivity: nasal bones are slightly shortened relative to controls or homozygotes on the mixed background
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Allelic
Composition |
Nkd1tm1Kwha/Nkd1+
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Genetic
Background |
involves: 129S/SvEv |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd1tm1Kwha mutation
(1 available);
any
Nkd1 mutation
(17 available)
|
|
|
reproductive system
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N |
• mice are viable and fertile
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Allelic
Composition |
Nkd1tm1Kwha/Nkd1+
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Genetic
Background |
involves: 129S/SvEv * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd1tm1Kwha mutation
(1 available);
any
Nkd1 mutation
(17 available)
|
|
|
reproductive system
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N |
• mice are viable and fertile
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behavior/neurological
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• significantly higher rate of cannabilization of offspring prior to weaning is observed in females having no or one wild-type copy of Nkd1 or Nkd2 (35% of 46 litters of females with one or no wild-type copies of either allele compared to only 14% of 51 litters of Nkd1-null or Nkd2-null homozygous females)
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reproductive system
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N |
• mice are viable and fertile
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behavior/neurological
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• significantly higher rate of cannabilization of offspring prior to weaning is observed in females having no or one wild-type copy of Nkd1 or Nkd2 (35% of 46 litters of females with one or no wild-type copies of either allele compared to only 14% of 51 litters of Nkd1-null or Nkd2-null homozygous females)
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craniofacial
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• at 2 months, skulls of mice are slightly shortened
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• at 2 months, nasal bones are slightly shortened relative to controls
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skeleton
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• at 2 months, skulls of mice are slightly shortened
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• at 2 months, nasal bones are slightly shortened relative to controls
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growth/size/body
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• at 2 months, nasal bones are slightly shortened relative to controls
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respiratory system
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• at 2 months, nasal bones are slightly shortened relative to controls
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Analysis Tools