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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ebf2tm2.1(Zfp423)Reed
targeted mutation 2.1, Randall R Reed
MGI:3714342
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ebf2tm2.1(Zfp423)Reed/Ebf2+ involves: 129 * C57BL/10J MGI:5461574
ht2
 		Ebf2tm2.1(Zfp423)Reed/Ebf2+ Not Specified MGI:3714636
cx3
 		Ebf2tm2.1(Zfp423)Reed/Ebf2+
Omptm1Mom/Omp+ 		involves: 129S2/SvPas MGI:3714637


Genotype
MGI:5461574
ht1
Allelic
Composition		 Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic
Background		 involves: 129 * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm2.1(Zfp423)Reed mutation (0 available); any Ebf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired neuron differentiation ( J:190934 )
• apparent arrest of olfactory sensory neuron differentiation
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

taste/olfaction
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

cellular
impaired neuron differentiation ( J:190934 )
• apparent arrest of olfactory sensory neuron differentiation

craniofacial
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

respiratory system
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

growth/size/body
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons




Genotype
MGI:3714636
ht2
Allelic
Composition		 Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm2.1(Zfp423)Reed mutation (0 available); any Ebf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal olfactory epithelium morphology ( J:122275 )
• fewer number of mature cells due to an increase in apoptosis
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

nervous system
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons
abnormal olfactory bulb morphology ( J:122275 )
• the dorsal olfactory bulb surface is largely devoid of glomeruli and few projecting axons reaching the dorsal surface migrating along aberrant paths instead of converging
• the olfactory bulb lack an extensive olfactory neuronal layer and glomerular layer at the dorsal and lateral olfactory bulb surface
• however, some glomeruli remain on the medial surface
• axonal growth occurs but the majority fail to innervate the bulb
abnormal olfactory nerve morphology ( J:122275 )
• the dorsal surface of the olfactory bulb lacks an olfactory nerve layer

growth/size/body
abnormal olfactory epithelium morphology ( J:122275 )
• fewer number of mature cells due to an increase in apoptosis
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons
decreased body size ( J:122275 )

respiratory system
abnormal olfactory epithelium morphology ( J:122275 )
• fewer number of mature cells due to an increase in apoptosis
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

craniofacial
abnormal olfactory epithelium morphology ( J:122275 )
• fewer number of mature cells due to an increase in apoptosis
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons




Genotype
MGI:3714637
cx3
Allelic
Composition		 Ebf2tm2.1(Zfp423)Reed/Ebf2+
Omptm1Mom/Omp+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm2.1(Zfp423)Reed mutation (0 available); any Ebf2 mutation (30 available)
Omptm1Mom mutation (2 available); any Omp mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

craniofacial
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

respiratory system
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

growth/size/body
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory