Phenotypes associated with this allele

• Allele Symbol: Zfp423^Gt(XB409)Byg
• Allele Name: gene trap XB409, BayGenomics
• Allele ID: MGI:3714339
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4879987

Genotype
MGI:4879987

hm1

• Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:122275 , J:122606 )

• die within one day of birth (J:122275)

• die within 1 day of birth except two (from 31 litters) survive to 3 weeks (J:122606)

postnatal lethality, complete penetrance ( J:122606 )

• two (from 31 litters) survived to 3 weeks

growth/size/body

decreased body size ( J:122606 )

• smaller than littermates

nervous system

abnormal cerebellar plate morphology ( J:122606 )

• smaller cerebellar plate at the hindbrain

abnormal brain interventricular foramen morphology ( J:122606 )

• enlarged interventricular foramen that connects the lateral ventricles with the third ventricle in the forebrain at E15.5

• form a gap in the ventral midline area at the forebrain

enlarged fourth ventricle ( J:122606 )

• enlarged fourth ventricle at the hindbrain

abnormal medulla oblongata morphology ( J:122606 )

• smaller medulla oblongata at the hindbrain

abnormal forebrain morphology ( J:122606 )

• reduced septum in the forebrain at E15.5

enlarged lateral ventricles ( J:122606 )

• enlarged lateral ventricles in the forebrain at E15.5

behavior/neurological

ataxia ( J:122606 )

• severe ataxia in mice survive to 3 weeks

• unable to maintain their balance and show poorly coordinated movement