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Allele Symbol Allele Name Allele ID |
Cul3tm1Jdsr targeted mutation 1, Jeffrey D Singer MGI:3714267 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• livers targeted with Cre adenovirus have larger cell and nuclear size
• livers targeted with Cre adenovirus exhibit increased proliferation
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• livers targeted with Cre adenovirus are 3 times heavier than in controls
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• mouse embryonic fibroblast cultures targeted with Cre adenovirus have 20% of cells in S phase compared to 15% in wild-type
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• after infection with a retroviral Cre, mouse embryonic fibroblasts undergo increased apoptosis
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• livers targeted with Cre adenovirus are 3 times heavier than in controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• deformed hippocampus
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• mice die before age P17
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer entries into and time spent in open arms in elevated plus maze test
• normal total distance travelled and time spent in closed arms in elevated plus maze test
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• less time spent in center in open field test
• normal distance traveled in open field test
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• reduced social preference index when introduced to novel mouse and novel inanimate object in three-chamber test
• reduced social preference index when introduced to novel mouse and known mouse in three-chamber test
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| N |
• normal cerebral cortex, corpus callosum and hippocampus morphology and brain weight
• normal neuron morphology in CA1 and hippocampal regions and in cerebral neocortex layers
• normal length and complexity of apical and basal dendrites of hippocampal CA1 neurons
• normal resting membrane potential (RMP) in hippocampal CA1 pyramidal neurons
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• increased number of spines on apical dendrites of hippocampal CA1 neurons
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• increased mEPSC frequency in hippocampal CA1 pyramidal neurons
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• increased mIPSC frequency in hippocampal CA1 pyramidal neurons
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| N |
• viable and normal lifespan
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| N |
• normal body size
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| N |
• fertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• deformed hippocampus
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• mice die before age P17
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal latency to fall in rotarod test
• normal distance traveled in open field test
• normal number of arm entries and spontaneous alterations in Y-maze test
• normal time and number of grooming episodes
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• fewer entries into and time spent in open arms in elevated plus maze test
• normal total distance travelled and time spent in closed arms in elevated plus maze test
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• less time spent in center in open field test
• normal distance traveled in open field test
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• reduced social preference index when introduced to novel mouse and novel inanimate object in three-chamber test
• reduced social preference index when introduced to novel mouse and known mouse in three-chamber test
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| N |
• normal cerebral cortex, corpus callosum and hippocampus morphology and brain weight
• normal latency to localize buried food pellets in olfactory sensing test
• normal neuron morphology in CA1 and CA3 hippocampal regions and in cerebral neocortex layers at age P60
• normal length and complexity of apical and basal dendrites of hippocampal CA1 neurons at age P60
• normal resting membrane potential (RMP) in hippocampal CA1 pyramidal neurons at age P60
• normal number of inhibitory synapses in hippocampal CA1 pyramidal neurons at age P15
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• increased number of spines on apical dendrites of hippocampal CA1 neurons at age P15 and P60
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• increased AP frequency in response to injected currents in hippocampal CA1 pyramidal neurons at age P60
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• higher rate of successful responses and synaptic efficacy to minimal stimulation in hippocampal CA1 pyramidal neurons at age P60
• increased EPSC/IPSC ratio in hippocampal CA1 pyramidal neurons at age P60
• normal synaptic potency to minimal stimulation in hippocampal CA1 pyramidal neurons at age P60
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• increased mEPSC frequency in hippocampal CA1 pyramidal neurons at age P15 and P60
• normal mEPSC amplitude in hippocampal CA1 pyramidal neurons at age P15 and P60
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• increased mIPSC frequency in hippocampal CA1 pyramidal neurons at age P60
• normal mIPSC amplitude in hippocampal CA1 pyramidal neurons at age P60
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• reduced paired-pulse ratio in hippocampal CA1 pyramidal neurons at age P60
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| N |
• viable and normal lifespan
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| N |
• normal body size
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| N |
• fertile
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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