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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Leprtm2Mgmj
targeted mutation 2, Martin G Myers, Jr
MGI:3713767
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Leprtm2Mgmj/Leprtm2Mgmj B6.Cg-Leprtm2Mgmj MGI:3713769
hm2
 		Leprtm2Mgmj/Leprtm2Mgmj Not Specified MGI:3837370
ht3
 		Leprtm2Mgmj/Lepr+ B6.Cg-Leprtm2Mgmj MGI:3713770


Genotype
MGI:3713769
hm1
Allelic
Composition		 Leprtm2Mgmj/Leprtm2Mgmj
Genetic
Background		 B6.Cg-Leprtm2Mgmj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm2Mgmj mutation (1 available); any Lepr mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating insulin level ( J:122056 )
• in young females fed ad libitum or older females on a high fat diet
decreased circulating leptin level ( J:122056 )
• in males and females

adipose tissue
abnormal fat pad morphology ( J:122056 )
• fat pads are decreased in females regardless of diet
decreased gonadal fat pad weight ( J:122056 )
• gonadal fat pad weight in older female mice is decreased

growth/size/body
decreased body weight ( J:122056 )
• female weight in older mice is decreased on a normal or high fat diet




Genotype
MGI:3837370
hm2
Allelic
Composition		 Leprtm2Mgmj/Leprtm2Mgmj
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm2Mgmj mutation (1 available); any Lepr mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased insulin secretion ( J:145998 )
• leptin-treated islet cells exhibit decreased insulin secretion compared to similarly treated wild-type islets

homeostasis/metabolism
decreased insulin secretion ( J:145998 )
• leptin-treated islet cells exhibit decreased insulin secretion compared to similarly treated wild-type islets




Genotype
MGI:3713770
ht3
Allelic
Composition		 Leprtm2Mgmj/Lepr+
Genetic
Background		 B6.Cg-Leprtm2Mgmj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm2Mgmj mutation (1 available); any Lepr mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating insulin level ( J:122056 )
• in young females fed ad libitum or older females on a high fat diet




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory