Phenotypes associated with this allele

• Allele Symbol: Slc39a2^tm1Gka
• Allele Name: targeted mutation 1, Glen K Andrews
• Allele ID: MGI:3712865
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc39a2^tm1Gka/Slc39a2^tm1Gka	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3715204

Genotype
MGI:3715204

hm1

• Allelic Composition: Slc39a2^tm1Gka/Slc39a2^tm1Gka
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryonic growth retardation ( J:121899 )

• when pregnant mice are fed a zinc-deficient diet from day 8 of gestation, 57% of embryos on day 14 are growth-retarded, compared to ~14% of wild-type embryos from control females fed a zinc-deficient diet

growth/size/body

embryonic growth retardation ( J:121899 )

• when pregnant mice are fed a zinc-deficient diet from day 8 of gestation, 57% of embryos on day 14 are growth-retarded, compared to ~14% of wild-type embryos from control females fed a zinc-deficient diet

craniofacial

abnormal craniofacial morphology ( J:121899 )

• at E14, ~57% of embryos from females fed a zinc-deficient diet show craniofacial abnormalities compared to 14% of embryos from wild-type females

limbs/digits/tail

abnormal limb development ( J:121899 )

• at E14, about 57% of embryos from females fed a zinc-deficient diet show abnormal limb differentiation compared to 14% of embryos from wild-type females

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:121899 )

• during zinc deficiency, calcium levels in mutant embryo rise about 75% compared to 25% in wild-type embryos

abnormal liver iron level ( J:121899 )

• iron accumulation in the liver during zinc deficiency is significantly less in mutants than in wild-type mice; mice show moderate increase in iron levels after 6 weeks, compared to a doubling of the levels after 5 weeks in wild-type mice

liver/biliary system

abnormal liver iron level ( J:121899 )

• iron accumulation in the liver during zinc deficiency is significantly less in mutants than in wild-type mice; mice show moderate increase in iron levels after 6 weeks, compared to a doubling of the levels after 5 weeks in wild-type mice

integument

ruffled hair ( J:121899 )

• most adult females fed a zinc deficient diet for 6 weeks have ruffled fur, similar to observations made for wild-type females fed a zinc-deficient diet

scaly skin ( J:121899 )

• most adult females fed a zinc-deficient diet for 6 weeks have scaly tails and foot pads, similar to observations made for wild-type females fed a zinc-deficient diet