Phenotypes associated with this allele

• Allele Symbol: Pygo1^tm1.1Ssp
• Allele Name: targeted mutation 1.1, S Steven Potter
• Allele ID: MGI:3712855
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp	involves: 129S1/Sv * 129X1/SvJ	MGI:3711518
cx2	Pygo1^tm1.1Ssp/Pygo1^+ Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp	involves: 129S1/Sv * 129X1/SvJ	MGI:3711520
cx3	Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp Pygo2^tm1.2Ssp/Pygo2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3711521
cx4	Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp Tg(CMV-cre)1Cgn/?	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss	MGI:3713467
cx5	Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss	MGI:3713468

Genotype
MGI:3711518

cx1

• Allelic Composition: Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp; Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

small lens ( J:121416 )

• the lens size is smaller than normal but not statistically different from that in Pygo2 null homozygotes

Genotype
MGI:3711520

cx2

• Allelic Composition: Pygo1^tm1.1Ssp/Pygo1⁺; Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

vision/eye

small lens ( J:121416 )

• the lens size is smaller than normal but not statistically different from that in Pygo2 null homozygotes

Genotype
MGI:3711521

cx3

• Allelic Composition: Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp; Pygo2^tm1.2Ssp/Pygo2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

vision/eye

vision/eye phenotype ( J:121416 )

N • lens sizes are normal

Genotype
MGI:3713467

cx4

• Allelic Composition: Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp; Tg(CMV-cre)1Cgn/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

normal phenotype

no abnormal phenotype detected ( J:121918 )

• mice are normal

Genotype
MGI:3713468

cx5

• Allelic Composition: Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp; Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

Small size, eye defects and exencephaly in Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp mice at E18.5

mortality/aging

neonatal lethality, incomplete penetrance ( J:121918 )

• mice have phenotypes similar to Pygo2^tm1.1Ssp single homozygotes and no synergy is observed in defect penetrance or severity

renal/urinary system

abnormal ureter development ( J:121918 )

• ureteric bud numbers are decreased 25% in mice with kidney defects

vision/eye

aphakia ( J:121918 )

• absent or rudimentary lens

abnormal retina morphology ( J:121918 )

• retinas are absent or rudimentary and the pigmented retina is folded

retina fold ( J:121918 )

• the pigmented retina is folded

growth/size/body

decreased fetal size ( J:121918 )

fetal growth retardation ( J:121918 )

• mice have phenotypes similar to Pygo2^tm1.1Ssp single homozygotes and no synergy is observed in defect penetrance or severity

nervous system

exencephaly ( J:121918 )

• seen in a small percentage of fetuses