About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pygo1tm1.1Ssp
targeted mutation 1.1, S Steven Potter
MGI:3712855
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp 		involves: 129S1/Sv * 129X1/SvJ MGI:3711518
cx2
 		Pygo1tm1.1Ssp/Pygo1+
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp 		involves: 129S1/Sv * 129X1/SvJ MGI:3711520
cx3
 		Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:3711521
cx4
 		Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Tg(CMV-cre)1Cgn/? 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss MGI:3713467
cx5
 		Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss MGI:3713468


Genotype
MGI:3711518
cx1
Allelic
Composition		 Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
small lens ( J:121416 )
• the lens size is smaller than normal but not statistically different from that in Pygo2 null homozygotes




Genotype
MGI:3711520
cx2
Allelic
Composition		 Pygo1tm1.1Ssp/Pygo1+
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
small lens ( J:121416 )
• the lens size is smaller than normal but not statistically different from that in Pygo2 null homozygotes




Genotype
MGI:3711521
cx3
Allelic
Composition		 Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:121416 )
N
• lens sizes are normal




Genotype
MGI:3713467
cx4
Allelic
Composition		 Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:121918 )
• mice are normal




Genotype
MGI:3713468
cx5
Allelic
Composition		 Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Small size, eye defects and exencephaly in Pygo1tm1.1Ssp/Pygo1tm1.1Ssp Pygo2tm1.2Ssp/Pygo2tm1.2Ssp mice at E18.5

mortality/aging
neonatal lethality, incomplete penetrance ( J:121918 )
• mice have phenotypes similar to Pygo2tm1.1Ssp single homozygotes and no synergy is observed in defect penetrance or severity

renal/urinary system
abnormal ureter development ( J:121918 )
• ureteric bud numbers are decreased 25% in mice with kidney defects

vision/eye
aphakia ( J:121918 )
• absent or rudimentary lens
abnormal retina morphology ( J:121918 )
• retinas are absent or rudimentary and the pigmented retina is folded
retina fold ( J:121918 )
• the pigmented retina is folded

growth/size/body
decreased fetal size ( J:121918 )
fetal growth retardation ( J:121918 )
• mice have phenotypes similar to Pygo2tm1.1Ssp single homozygotes and no synergy is observed in defect penetrance or severity

nervous system
exencephaly ( J:121918 )
• seen in a small percentage of fetuses




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory