All Phenotypes Lbx2<tm1Fchn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lbx2^tm1Fchn
targeted mutation 1, Fabian Chen
MGI:3712795

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lbx2^tm1Fchn/Lbx2^tm1Fchn	B6.129-Lbx2^tm1Fchn	MGI:3712863
hm2	Lbx2^tm1Fchn/Lbx2^tm1Fchn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6460288
cx3	Lbx2^tm1Fchn/Lbx2^tm1Fchn Pax3^Sp/Pax3^Sp	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3712864

Allelic Composition	Lbx2^tm1Fchn/Lbx2^tm1Fchn
Genetic Background	B6.129-Lbx2^tm1Fchn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbx2^tm1Fchn mutation (0 available); any Lbx2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:121890 )

N	• a decrease in expected ratio of 4-week old mice is observed but is not statistically significant on either background

Allelic Composition	Lbx2^tm1Fchn/Lbx2^tm1Fchn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbx2^tm1Fchn mutation (0 available); any Lbx2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:121890 )

• a decrease in expected ratio of 4-week old mice is observed but is not statistically significant on either background

Allelic Composition	Lbx2^tm1Fchn/Lbx2^tm1Fchn Pax3^Sp/Pax3^Sp
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbx2^tm1Fchn mutation (0 available); any Lbx2 mutation (10 available)
Pax3^Sp mutation (4 available); any Pax3 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

open neural tube ( J:121890 )

• defects seen with Pax3 homozygosity are not affected by Lbx2-deficiency at E10.5-13.5

exencephaly ( J:121890 )

• defects seen with Pax3 homozygosity are not affected by Lbx2-deficiency at E10.5-13.5

abnormal cranial ganglia morphology ( J:121890 )

• Lbx2 expression is significantly decreased with Pax3 deficiency

abnormal dorsal root ganglion morphology ( J:121890 )

• Lbx2 expression is significantly decreased with Pax3 deficiency

homeostasis/metabolism

edema ( J:121890 )

• defects seen with Pax3 homozygosity are not affected by Lbx2-deficiency at E10.5-13.5

embryo

open neural tube ( J:121890 )

• defects seen with Pax3 homozygosity are not affected by Lbx2-deficiency at E10.5-13.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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