Phenotypes associated with this allele

• Allele Symbol: Pou3f3^urehr2
• Allele Name: urea phenotype 2
• Allele ID: MGI:3712282
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pou3f3^urehr2/Pou3f3^urehr2	C3HeB/FeJ-Pou3f3^urehr2	MGI:3712574

Genotype
MGI:3712574

hm1

• Allelic Composition: Pou3f3^urehr2/Pou3f3^urehr2
• Genetic Background: C3HeB/FeJ-Pou3f3^urehr2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:121470 )

N • no renal alterations are histologically apparent relative to littermate controls at 4 months of age

decreased urine sodium level ( J:121470 )

• urine sodium/creatinine and chloride/creatinine ratios tend to be decreased in 24-hour urine and spot urine samples of phenotypic mutants

small kidney ( J:121470 )

decreased kidney weight ( J:121470 )

• phenotypic mutants (ie. mice with pathological plasma urea levels) at 4 months show decreased kidney weight and kidney-to-body weight ratio relative to controls

homeostasis/metabolism

increased circulating creatinine level ( J:121470 )

• increased levels are seen in phenotypic mutants

increased blood urea nitrogen level ( J:121470 )

• mice have pathological plasma urea levels with 70% penetrance (phenotypic mutants) when analyzed at 3 months (2 measurements >70 mg/dl within 3-week period) compared to controls

decreased circulating glucose level ( J:121470 )

• reduced plasma glucose is observed in phenotypic mutants

decreased urine sodium level ( J:121470 )

• urine sodium/creatinine and chloride/creatinine ratios tend to be decreased in 24-hour urine and spot urine samples of phenotypic mutants