Phenotypes associated with this allele

• Allele Symbol: Gnai2^tm1.1Rneu
• Allele Name: targeted mutation 1.1, Richard R Neubig
• Allele ID: MGI:3711989
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnai2^tm1.1Rneu/Gnai2^tm1.1Rneu	involves: 129S1/Sv * C57BL/6	MGI:3712869
ht2	Gnai2^tm1.1Rneu/Gnai2^+	B6.129S1-Gnai2^tm1.1Rneu	MGI:5508326

Genotype
MGI:3712869

hm1

• Allelic Composition: Gnai2^tm1.1Rneu/Gnai2^tm1.1Rneu
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:121385 )

• injection of carbachol lead to the death of one mouse

premature death ( J:121385 )

• mice exhibit reduced viability

cardiovascular system

decreased heart rate ( J:121385 )

• 5.1-fold enhancement in muscarinic-induced bradcycardic response

• carbachol injection results in severe bradycardia

• however, adenosine-induced bradcycardic response is not significantly different

increased heart rate ( J:121385 )

• procaterol-induced tachycardia is significantly attenuated at high doses

• however, there is a slightly negative chronotropic response to procaterol at low doses

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:121385 )

• injection of carbachol lead to the death of one mouse

increased physiological sensitivity to xenobiotic ( J:121385 )

• 5.1-fold enhancement in muscarinic-induced bradcycardic response

• carbachol injection results in severe bradycardia

• procaterol-induced tachycardia is significantly attenuated at high doses

• however, adenosine-induced bradcycardic response is not significantly different

• however, there is a slightly negative chronotropic response to procaterol at low doses

growth/size/body

decreased body weight ( J:121385 )

• homozygotes show reduced body weight relative to controls

Genotype
MGI:5508326

ht2

• Allelic Composition: Gnai2^tm1.1Rneu/Gnai2⁺
• Genetic Background: B6.129S1-Gnai2^tm1.1Rneu

nervous system

nervous system phenotype ( J:197965 )

N • mice exhibit normal epinephrine-induced reduction in burst frequency of induced epileptiform activity