Phenotypes associated with this allele

• Allele Symbol: Ago2^Gt(XE344)Byg
• Allele Name: gene trap XE344, BayGenomics
• Allele ID: MGI:3711987
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ago2^Gt(XE344)Byg/Ago2^Gt(XE344)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3712807
ht2	Ago2^Gt(XE344)Byg/Ago2^tm2Ghan	involves: 129P2/OlaHsd	MGI:4462373

Genotype
MGI:3712807

hm1

• Allelic Composition: Ago2^Gt(XE344)Byg/Ago2^Gt(XE344)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:121791 )

• no homozygous mice are born; developmental arrest at ~E5.5 is observed

embryo

embryonic growth arrest ( J:121791 )

• development of homozygous embryos appears to have arrested before E7.5 (at ~E5.5)

abnormal embryonic tissue morphology ( J:121791 )

• at E5.5, homozygous embryos are slightly morphologically misshapen compared to wild-type and heterozygous littermates

cellular

cellular phenotype ( J:121791 )

N • DNA methylation in imprinted genes appears to be maintained with Eif2c2-deficiency

Genotype
MGI:4462373

ht2

• Allelic Composition: Ago2^Gt(XE344)Byg/Ago2^tm2Ghan
• Genetic Background: involves: 129P2/OlaHsd

embryo

placental labyrinth hypoplasia ( J:161968 )

• thin

small placenta ( J:161968 )

• mice exhibit a hypotrophic placenta compared with wild-type mice

• however, the giant trophoblast cell and spongiform layers are normal