Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd80tm1Shr mutation
(12 available);
any
Cd80 mutation
(42 available)
Cd86tm2Shr mutation
(3 available);
any
Cd86 mutation
(38 available)
Tg(Ighm-Ctla4Ig/Cd80)1Jbs mutation
(0 available)
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immune system
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• mice show less insulitis compared to non-transgenic double nulls
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• mice have 0.3% CD4+CD25hiCD62L+ regulatory T cells compared to 4% in NOD controls
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• mice show 40% suppression of diabetes development compared to non-transgenic double null animals
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hematopoietic system
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• mice have 0.3% CD4+CD25hiCD62L+ regulatory T cells compared to 4% in NOD controls
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endocrine/exocrine glands
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• mice show less insulitis compared to non-transgenic double nulls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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immune system
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N |
• B and T cells develop normally in transgenic mice; peripheral B and T cells show similar development and function to polyclonasl stimuli like LPS, anti-IgM, anti-CD3 and anti-CD28 as wild-type cells
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• B cells from mutants inhibit proliferation and cytokine production by wild-type T cells in culture
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hematopoietic system
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• B cells from mutants inhibit proliferation and cytokine production by wild-type T cells in culture
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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immune system
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N |
• no differences in insulin autoantibody responses are observed compared to NOD controls at 5, 10, 20, or 30 weeks
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• diabetes incidence in mice is 33% by 30 weeks of age, compared to 70% in NOD controls; mice display 25% incidence of diabetes by 19 weeks of age, compared to the same incidence by 12.2 weeks in NOD controls
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Analysis Tools