Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1.1Mds mutation
(0 available);
any
Cxadr mutation
(15 available)
Cxadrtm1Mds mutation
(0 available);
any
Cxadr mutation
(15 available)
Tg(Tnnt2-cre)5Blh mutation
(1 available)
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mortality/aging
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• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes
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cardiovascular system
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• at E10.5, engorgement of the cardinal veins is apparent
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• hyperplasia of proximal heart tube is seen at E10.5
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• sinuatrial valves, located at the junction between sinus venosus and atrium in wild-type embryos, are absent
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1Mds mutation
(0 available);
any
Cxadr mutation
(15 available)
Tg(Tnnt2-cre)5Blh mutation
(1 available)
|
|
|
mortality/aging
|
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes
|
cardiovascular system
|
• at E10.5, engorgement of the cardinal veins is apparent
|
|
• hyperplasia of proximal heart tube is seen at E10.5
|
|
• sinuatrial valves, located at the junction between sinus venosus and atrium in wild-type embryos, are absent
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1Mds mutation
(0 available);
any
Cxadr mutation
(15 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
|
|
|
mortality/aging
N |
• many conditional null mice are born alive and survive to adulthood (20/102)
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cardiovascular system
|
• sinuatrial valves show mild abnormalities in embryos, with only 1 embryo showing absence or attenuation comparable to constitutive null mice
|
|
• embryos show only mild or no abnormal ventricular thickening with little or no increase in proliferating cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1.1Mds mutation
(0 available);
any
Cxadr mutation
(15 available)
Cxadrtm1Mds mutation
(0 available);
any
Cxadr mutation
(15 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
|
|
|
mortality/aging
N |
• many conditional null mice are born alive and survive to adulthood (20/102)
|
cardiovascular system
|
• sinuatrial valves show mild abnormalities in embryos, with only 1 embryo showing absence or attenuation comparable to constitutive null mice
|
|
• embryos show only mild or no abnormal ventricular thickening with little or no increase in proliferating cells
|