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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hey2tm2Eno
targeted mutation 2, Eric N Olson
MGI:3711159
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hey2tm2Eno/Hey2tm2Eno 129-Hey2tm2Eno MGI:3711332
hm2
 		Hey2tm2Eno/Hey2tm2Eno involves: 129S6/SvEvTac * C57BL/6 MGI:3711331
cn3
 		Hey2tm1Eno/Hey2tm2Eno
Tg(Tagln-cre)1Her/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3711335
cn4
 		Hey2tm1Eno/Hey2tm2Eno
Tg(Nkx2-5-cre)9Eno/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3711334
cn5
 		Hey2tm1Eno/Hey2tm2Eno
Tg(Tek-cre)1Ywa/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3711336
cx6
 		Hey2tm2Eno/Hey2tm2Eno
Rr76em1Ona/Rr76em1Ona 		involves: 129/SvEv * C57BL/6 * DBA MGI:6467007


Genotype
MGI:3711332
hm1
Allelic
Composition		 Hey2tm2Eno/Hey2tm2Eno
Genetic
Background		 129-Hey2tm2Eno
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm2Eno mutation (0 available); any Hey2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:121577 )
• mice die in the neonatal period

cardiovascular system
ventricular septal defect ( J:121577 )
• all neonates show ventricular septal defects (VSDs)




Genotype
MGI:3711331
hm2
Allelic
Composition		 Hey2tm2Eno/Hey2tm2Eno
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm2Eno mutation (0 available); any Hey2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:121577 )
• mice die in the neonatal period

cardiovascular system
ventricular septal defect ( J:121577 )
• all neonates show ventricular septal defects (VSDS)




Genotype
MGI:3711335
cn3
Allelic
Composition		 Hey2tm1Eno/Hey2tm2Eno
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Eno mutation (1 available); any Hey2 mutation (29 available)
Hey2tm2Eno mutation (0 available); any Hey2 mutation (29 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:121577 )
• mice display partial perinatal lethality

cardiovascular system
ventricular septal defect ( J:121577 )
• VSDs are observed
decreased cardiac muscle contractility ( J:121577 )
• contractile dysfunction observed

muscle
decreased cardiac muscle contractility ( J:121577 )
• contractile dysfunction observed




Genotype
MGI:3711334
cn4
Allelic
Composition		 Hey2tm1Eno/Hey2tm2Eno
Tg(Nkx2-5-cre)9Eno/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Eno mutation (1 available); any Hey2 mutation (29 available)
Hey2tm2Eno mutation (0 available); any Hey2 mutation (29 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:121577 )
• adult mice have grossly enlarged hearts
abnormal heart ventricle morphology ( J:121577 )
• base of dilated right ventricle merges with interventricular septum above apex of heart; this is apparent by E13.5 and persists in adults
• at 6 weeks of age, ectopic activation of atrial regular and structural genes (>10-fold greater than wild-type littermates) is observed in ventricular myocardium
abnormal interventricular septum morphology ( J:121577 )
• VSDs are not observed in all mice, however, some show VSDs or delay of ventricular septal formation at E13.5-17.5
abnormal heart left ventricle morphology ( J:121577 )
• at 6 weeks of age, mice show an increase in systolic left ventricular internal diameter (LVID)
• normal diastolic left ventricular internal diameter does not change significantly relative to wild-type
• atrial naturietic factor (ANF) and Tbx5 expression is increased in left ventricle at E17.5, whereas expression is seen in atria and trabecular cells in wild-type
decreased cardiac muscle contractility ( J:121577 )
• deterioration in heart contractility, accompanied by decreased fractional shortening (FS)

muscle
decreased cardiac muscle contractility ( J:121577 )
• deterioration in heart contractility, accompanied by decreased fractional shortening (FS)

growth/size/body
enlarged heart ( J:121577 )
• adult mice have grossly enlarged hearts




Genotype
MGI:3711336
cn5
Allelic
Composition		 Hey2tm1Eno/Hey2tm2Eno
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Eno mutation (1 available); any Hey2 mutation (29 available)
Hey2tm2Eno mutation (0 available); any Hey2 mutation (29 available)
Tg(Tek-cre)1Ywa mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121577 )
N
• mice are viable

cardiovascular system
cardiovascular system phenotype ( J:121577 )
N
• no detectable defects of cardiac structure are found




Genotype
MGI:6467007
cx6
Allelic
Composition		 Hey2tm2Eno/Hey2tm2Eno
Rr76em1Ona/Rr76em1Ona
Genetic
Background		 involves: 129/SvEv * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm2Eno mutation (0 available); any Hey2 mutation (29 available)
Rr76em1Ona mutation (0 available); any Rr76 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:288309 )
N
• mice exhibit normal cardiac morphology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory