Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm2Eno mutation
(0 available);
any
Hey2 mutation
(30 available)
|
|
|
mortality/aging
|
• mice die in the neonatal period
|
cardiovascular system
|
• all neonates show ventricular septal defects (VSDs)
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm2Eno mutation
(0 available);
any
Hey2 mutation
(30 available)
|
|
|
mortality/aging
|
• mice die in the neonatal period
|
cardiovascular system
|
• all neonates show ventricular septal defects (VSDS)
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Eno mutation
(1 available);
any
Hey2 mutation
(30 available)
Hey2tm2Eno mutation
(0 available);
any
Hey2 mutation
(30 available)
Tg(Tagln-cre)1Her mutation
(2 available)
|
|
|
mortality/aging
|
• mice display partial perinatal lethality
|
cardiovascular system
|
• contractile dysfunction observed
|
muscle
|
• contractile dysfunction observed
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Eno mutation
(1 available);
any
Hey2 mutation
(30 available)
Hey2tm2Eno mutation
(0 available);
any
Hey2 mutation
(30 available)
Tg(Nkx2-5-cre)9Eno mutation
(0 available)
|
|
|
cardiovascular system
|
• adult mice have grossly enlarged hearts
|
|
• base of dilated right ventricle merges with interventricular septum above apex of heart; this is apparent by E13.5 and persists in adults
• at 6 weeks of age, ectopic activation of atrial regular and structural genes (>10-fold greater than wild-type littermates) is observed in ventricular myocardium
|
|
• VSDs are not observed in all mice, however, some show VSDs or delay of ventricular septal formation at E13.5-17.5
|
|
• at 6 weeks of age, mice show an increase in systolic left ventricular internal diameter (LVID)
• normal diastolic left ventricular internal diameter does not change significantly relative to wild-type
• atrial naturietic factor (ANF) and Tbx5 expression is increased in left ventricle at E17.5, whereas expression is seen in atria and trabecular cells in wild-type
|
|
• deterioration in heart contractility, accompanied by decreased fractional shortening (FS)
|
muscle
|
• deterioration in heart contractility, accompanied by decreased fractional shortening (FS)
|
growth/size/body
|
• adult mice have grossly enlarged hearts
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Eno mutation
(1 available);
any
Hey2 mutation
(30 available)
Hey2tm2Eno mutation
(0 available);
any
Hey2 mutation
(30 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
|
|
|
mortality/aging
cardiovascular system
N |
• no detectable defects of cardiac structure are found
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm2Eno mutation
(0 available);
any
Hey2 mutation
(30 available)
Rr76em1Ona mutation
(0 available);
any
Rr76 mutation
(0 available)
|
|
|
cardiovascular system
N |
• mice exhibit normal cardiac morphology
|