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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a2tm1.1Mcbr
targeted mutation 1.1, Daniel J McBride
MGI:3711122
Summary 6 genotypes


Genotype
MGI:3711190
hm1
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2tm1.1Mcbr
Genetic
Background		 B6.129(Cg)-Col1a2tm1.1Mcbr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:178743 )
• no homozygous mice are recovered but dead pups are found within 24 hours of birth
preweaning lethality, complete penetrance ( J:121691 )
• homozygous mice do not survive to weaning age




Genotype
MGI:5300563
ht2
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 (A/J x B6.129-Col1a2tm1.1Mcbr)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:178743 )

skeleton
decreased bone mineral content ( J:178743 )
• decreased bone mineral content
• lower cortical volumetric tissue mineral content
increased bone mineral density ( J:178743 )
• Background Sensitivity: bone mineral density is highest on the mixed A/J and C57BL/6 background compared to F1 crosses to BALB/cByJ, FVB/NJ, or C3H/HeJ
increased volumetric bone mineral density ( J:178743 )
• cortical volumetric tissue mineral density (vTMD) is elevated in the femur
decreased bone trabecula number ( J:178743 )
• fewer and more widely spaced trabeculae
decreased bone strength ( J:178743 )
• femurs are weaker and more brittle

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
osteogenesis imperfecta DOID:12347 OMIM:PS166200
 J:178743




Genotype
MGI:3711191
ht3
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 B6.129(Cg)-Col1a2tm1.1Mcbr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:121691 )
• mice show reduced body mass compared to wild-type




Genotype
MGI:5300564
ht4
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 (BALB/cByJ x B6.129-Col1a2tm1.1Mcbr)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:178743 )

skeleton
decreased bone mineral content ( J:178743 )
• decreased bone mineral content
• lower cortical volumetric tissue mineral content
increased bone mineral density ( J:178743 )
• Background Sensitivity: bone mineral density is higher on the mixed BALB/cByJ and C57BL/6 background compared to F1 crosses to FVB/NJ, or C3H/HeJ but lower compared to F1 crosses to A/J
increased volumetric bone mineral density ( J:178743 )
• cortical volumetric tissue mineral density (vTMD) is elevated in the femur
decreased bone trabecula number ( J:178743 )
• fewer and more widely spaced trabeculae
decreased bone strength ( J:178743 )
• femurs are weaker and more brittle

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
osteogenesis imperfecta DOID:12347 OMIM:PS166200
 J:178743




Genotype
MGI:5300565
ht5
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 (C3H/HeJ x B6.129-Col1a2tm1.1Mcbr)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:178743 )

skeleton
decreased bone mineral content ( J:178743 )
• decreased bone mineral content
• lower cortical volumetric tissue mineral content
increased bone mineral density ( J:178743 )
• Background Sensitivity: bone mineral density is lowest on the mixed C3H/HeJ and C57BL/6 background compared to F1 crosses to A/J, BALB/cByJ, or FVB/NJ
increased volumetric bone mineral density ( J:178743 )
• cortical volumetric tissue mineral density (vTMD) is elevated in the femur
decreased bone trabecula number ( J:178743 )
• fewer and more widely spaced trabeculae
decreased bone strength ( J:178743 )
• femurs are weaker and more brittle

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
osteogenesis imperfecta DOID:12347 OMIM:PS166200
 J:178743




Genotype
MGI:5300566
ht6
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 (FVB/NJ x B6.129-Col1a2tm1.1Mcbr)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:178743 )

skeleton
increased bone mineral density ( J:178743 )
• Background Sensitivity: bone mineral density is higher on the mixed FVB/NJ and C57BL/6 background compared to F1 crosses to C3H/HeJ but lower compared to F1 crosses to A/J or BALB/cByJ
increased volumetric bone mineral density ( J:178743 )
• cortical volumetric tissue mineral density (vTMD) is elevated in the femur
decreased bone trabecula number ( J:178743 )
• fewer and more widely spaced trabeculae
decreased bone strength ( J:178743 )
• femurs are weaker and more brittle

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
osteogenesis imperfecta DOID:12347 OMIM:PS166200
 J:178743




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory