About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bicc1tm1Emdr
targeted mutation 1, E M de Robertis
MGI:3711021
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bicc1tm1Emdr/Bicc1tm1Emdr B6SJL-Bicc1tm1Emdr MGI:3711062
hm2
 		Bicc1tm1Emdr/Bicc1tm1Emdr B6SJL-Bicc1tm1Emdr/J MGI:4442642


Genotype
MGI:3711062
hm1
Allelic
Composition		 Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic
Background		 B6SJL-Bicc1tm1Emdr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicc1tm1Emdr mutation (1 available); any Bicc1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:121683 )
• mice survive a for a few weeks after birth

renal/urinary system
polycystic kidney ( J:121683 )
• homozygotes have polycystic kidneys

growth/size/body
polycystic kidney ( J:121683 )
• homozygotes have polycystic kidneys

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autosomal recessive polycystic kidney disease DOID:0110861 J:121683




Genotype
MGI:4442642
hm2
Allelic
Composition		 Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic
Background		 B6SJL-Bicc1tm1Emdr/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicc1tm1Emdr mutation (1 available); any Bicc1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:158678 )
• fewer than expected mice are present from E14.5 to birth
perinatal lethality, incomplete penetrance ( J:158678 )
• more than half of mice die perinatally

renal/urinary system
polycystic kidney ( J:158678 )
• as early as E15.5, mice develop cysts with squamous cell lining unlike wild-type mice
• cysts develop from glomeruli, proximal tubules, and the thick ascending limb of the loop of Henle and collecting ducts
enlarged kidney ( J:158678 )
• bilaterally in surviving mice
abnormal nephrogenic zone morphology ( J:158678 )
• mice exhibit a reduction in the nephrogenic zone compared with wild-type mice

liver/biliary system

endocrine/exocrine glands

growth/size/body
biliary cyst ( J:158678 )
pancreas cyst ( J:158678 )
polycystic kidney ( J:158678 )
• as early as E15.5, mice develop cysts with squamous cell lining unlike wild-type mice
• cysts develop from glomeruli, proximal tubules, and the thick ascending limb of the loop of Henle and collecting ducts
enlarged kidney ( J:158678 )
• bilaterally in surviving mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory